Evidence map›Paper›PMID 40734685›Full record

ArticleTherapeutic advances in musculoskeletal disease2025

Deep learning meets chest X-rays: a promising approach for predicting future compression fracture risk.

Kai-Chieh Chen, Shan-Yueh Chang, Yuan-Ping Chao, Dung-Jang Tsai, Wei-Chou Chang, Yu-Shiou Weng, Chin Lin, Wen-Hui Fang

Abstract read
In one paragraph

Article in Therapeutic advances in musculoskeletal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kai-Chieh ChenGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.ORCID https://orcid.org/0009-0000-9369-3851
Shan-Yueh ChangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Yuan-Ping ChaoDepartment of Family and Community Medicine, School of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Dung-Jang TsaiMedical Technology Education Center, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Wei-Chou ChangDepartment of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Yu-Shiou WengDepartment of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Chin LinGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Wen-Hui FangDepartment of Family and Community Medicine, School of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.ORCID https://orcid.org/0000-0002-0574-5736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Osteoporotic fractures are a significant global health concern, leading to disability and reduced quality of life. Existing diagnostic tools, such as dual-energy X-ray absorptiometry (DXA) and the Fracture Risk Assessment Tool, have limitations, such as dependence on structured datasets and difficulty identifying all high-risk individuals. Objectives: This study aimed to develop and validate an AI-enabled chest X-ray (AI-CXR) model for predicting osteoporotic fracture risk, offering a noninvasive, accessible alternative. Design: This is a retrospective study. Methods: This study analyzed 166,571 CXR from 78,548 patients in Taiwan, with internal validation on 31,977 X-rays and external validation on 36,677 X-rays. The datasets were divided into groups with and without Results: The AI-CXR model demonstrated superior predictive accuracy compared to DXA, particularly for patients without Conclusion: The AI-CXR model provides a cost-effective, noninvasive tool for osteoporotic fracture risk assessment, enabling improved early detection and personalized intervention across diverse clinical settings.

Indexed as

artificial intelligencechest X-raydeep learningosteoporosis T-scoresosteoporotic fractures

Identifiers

PMID40734685
PMCPMC12304508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.