Evidence map›Paper›PMID 40734678›Full record

ArticleiScience2025

Preadipocyte-induced upregulation of IGFBP5 enhances ovarian cancer tumorigenesis via CREB signaling.

Jennifer A Waters, Cassidy Lucht, Sofia Howe, Gregory J Jordan, Ixchel Urbano, Samuel F Gilbert, Richard M Cripps, Mikella Robinson, Carrie D House

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer A WatersDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Cassidy LuchtDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Sofia HoweDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Gregory J JordanDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Ixchel UrbanoDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Samuel F GilbertDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Richard M CrippsDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Mikella RobinsonDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Carrie D HouseDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.

Funding

The Research Infrastructure Core of SDSU HealthLINK Center for Transdisciplinary Health Disparities ResearchU54MD012397 · NIMHD · SAN DIEGO STATE UNIVERSITY · PI GUADALUPE X AYALA · 2018 to 2026
$39.0M
Building Capacity and Infrastructure for Population Health and Health Disparities Research at San Diego State UniversityS21MD010690 · NIMHD · SAN DIEGO STATE UNIVERSITY · PI AYALA, GUADALUPE X, CASTILLO, JOSE E · 2016 to 2020
$10.0M
NRSA Training CoreTL1DK143270 · NIDDK · UNIVERSITY OF WASHINGTON · PI HUNTER WESSELLS · 2024 to 2026
$2.1M
Alternative NF-kB activation in post-chemotherapy setting to elucidate novel mechanisms of ovarian cancer relapseR01CA260281 · NCI · SAN DIEGO STATE UNIVERSITY · PI Carrie Danielle House · 2022 to 2026
$2.1M
NCI NIH HHS R01 CA260281NIDDK NIH HHS TL1 DK143270NIMHD NIH HHS S21 MD010690NIMHD NIH HHS U54 MD012397
6 · The paper itself

Abstract

Dissemination of ovarian cancer cells during metastasis is heavily influenced by omental cells from the adipose tumor microenvironment. We previously found that omental adipocyte precursors, or preadipocytes, promote stress tolerance and tumorigenesis of ovarian cancer cells and this was correlated with upregulation of insulin-like growth factor-binding protein 5 (IGFBP5). Here, we tested whether IGFBP5 mediates stress tolerance and tumorigenesis. Using

Indexed as

CancerMolecular biology

Identifiers

PMID40734678
PMCPMC12304763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.