Evidence map›Paper›PMID 40734674›Full record

ArticleiScience2025

RACK7 senses and fine-tunes enhancer activity.

Li Dong, Daixuan Zhang, Ying Cai, Min Zeng, Mandi Mu, Peng Zhao, Jin Wang, Siyi Cheng, Qingqing Cai, Jian Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Li DongLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Daixuan ZhangLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Ying CaiLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Min ZengLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Mandi MuLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Peng ZhaoLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jin WangLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Siyi ChengLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Qingqing CaiLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jian ZhangLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yajun HuLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Lei ZhangLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Li TanLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Feizhen WuLaboratory of Epi-Informatics, Intelligent Medicine Institute, Fudan University, Shanghai, China.
Yujiang Geno ShiLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenqi XuLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hongjie ShenLongevity and Aging Institute, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhancers regulate dynamic gene expression in a spatiotemporal specific manner. A number of positive as well as negative regulators of enhancers have been reported so far. However, whether and how these regulators sense enhancer activity dynamics remains unclear. In this study, we show that a specific enhancer regulator, RACK7, swiftly re-distributes from repressed enhancers to activated enhancers in response to a plethora of acute stimulations. We further show that this process depends on transcription and RACK7 positively regulates enhancer activation by promoting the recruitment of RNA polymerase II. Taken together, our findings suggest that RACK7 senses enhancer activity changes and facilitates their activation during acute stimulations.

Indexed as

BiochemistryMolecular mechanism of gene regulationTranscriptomics

Identifiers

PMID40734674
PMCPMC12304917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.