Evidence map›Paper›PMID 40734673›Full record

ArticleiScience2025

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis.

Hisako Akatsuka, Tomohiro Kashikawa, Kaori Masuhara, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Chisa Okada-Yamaguchi, Yoshinori Okada, Masayuki Tanaka, Takahiro Suzuki and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Hisako AkatsukaDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Tomohiro KashikawaDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Kaori MasuharaDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Mizuki TokusanaiDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Chenyang LiDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Yumi IidaMedical Science College Office, Tokai University, Isehara, Kanagawa 259-1193, Japan.
Chisa Okada-YamaguchiMedical Science College Office, Tokai University, Isehara, Kanagawa 259-1193, Japan.
Yoshinori OkadaMedical Science College Office, Tokai University, Isehara, Kanagawa 259-1193, Japan.
Masayuki TanakaMedical Science College Office, Tokai University, Isehara, Kanagawa 259-1193, Japan.
Takahiro SuzukiDepartment of Ophthalmology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Norio YamamotoDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Katsuto HozumiDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Tomoaki TanakaDepartment of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.
Hirofumi NakaokaHuman Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
Kazuyoshi HosomichiHuman Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
Yu HamaguchiFaculty of Science and Engineering, Waseda University, 55N-06-10, 3-4-1 Okubo Shinjuku-ku, Tokyo 169-8555, Japan.
Michiaki HamadaFaculty of Science and Engineering, Waseda University, 55N-06-10, 3-4-1 Okubo Shinjuku-ku, Tokyo 169-8555, Japan.
Yoshiki ShiraishiDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Akihide KamiyaDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Yoshihiko NakamuraDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Kaito HaradaDepartment of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Abd Aziz IbrahimTranslational Molecular Therapeutics Laboratory, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Takashi YahataTranslational Molecular Therapeutics Laboratory, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Masato OhtsukaDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Naoya NakamuraDepartment of Pathology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Hiroyuki HosokawaDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Minoru KimuraInstitute of Medical Sciences, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Ituro InoueHuman Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
Takehito SatoDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AMBRA1, which was initially reported to be essential for nervous system development via autophagy and cell proliferation control, also functions as a tumor suppressor by regulating the ubiquitination of D-type cyclins through interaction with DDB1-Cullin4A/4 B E3 ligase. We had identified a missense mutation in

Indexed as

CancerCell biology

Identifiers

PMID40734673
PMCPMC12304916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.