Evidence map›Paper›PMID 40734522›Full record

ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Comparative Analysis of Inflammatory Response in Surgical Wound Drainage Fluid in Scoliosis Surgery: A Study of Neuromuscular vs. Idiopathic Patients.

Meredith J Crane, Robin L McKinney, Alexander R D Jordon, Craig P Eberson, Amanda M Jamieson

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Meredith J CraneDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.ORCID 0000-0001-9678-4265
Robin L McKinneyDivision of Pediatric Critical Care, Hasbro Children's Hospital and the Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Alexander R D JordonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Craig P EbersonPediatric Orthopedics Division, Hasbro Children's Hospital and the Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Amanda M JamiesonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-5781-9231

Funding

Influence of the lung microbiome on macrophage responses to lung damageR01HL126887 · NHLBI · BROWN UNIVERSITY · PI JAMIESON, AMANDA M · 2018 to 2022
$2.4M
Brown University Carney Institute Innovation AwardsBrown University Dean's Emerging Areas of New Science Award (DEANS)Brown University Seed AwardDefense Advanced Research Projects Agency (DARPA) Director's Award YFAA15D15AP00100NHLBI NIH HHS 3R01HL126887-05S1NHLBI NIH HHS R01 HL126887NHLBI NIH HHS R01HL126887
6 · The paper itself

Abstract

This study examines immune and inflammatory responses in draining wound fluid over the course of the early stages of wound healing in patients recovering from spinal fusion surgery. The inflammatory phase of wound healing is essential for setting the stage for successful tissue repair and preventing chronic or poorly healing wounds. Scoliosis can be idiopathic or occur secondary to neuromuscular disorders, which are known to be associated with poor wound healing outcomes. We hypothesised that neuromuscular scoliosis patients would exhibit differences in inflammatory wound healing markers compared to idiopathic scoliosis patients. Comparison of the cellular and cytokine contents of draining wound fluid revealed that several inflammatory cytokines were elevated in the neuromuscular scoliosis patient group compared to idiopathic, whereas the leukocyte contents were the same between groups. This study shows that draining wound fluid is a good source of cellular and soluble biomarkers for acute wound healing and can be used to determine changes in individuals at risk for wound healing complications.

Indexed as

Neuromuscular DiseasesScoliosisSpinal FusionSurgical WoundWound HealingAdolescentBiomarkersCytokinesDrainageFemaleFlow CytometryHumansInflammationMaleBiomarkersCytokinescytokineinflammationleukocytescoliosissurgerywound

Identifiers

PMID40734522
PMCPMC12403945

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.