Evidence map›Paper›PMID 40734436›Full record

ArticleCurrent drug delivery2026

Metformin-Embedded Hydrogels: A Promising Approach for Accelerating Healing in Diabetic Ulcers.

Jiaru Zhou, Xiangmei Liu, Tianyu Tang, Jiawei Liang, Huashen He, Yingyao Luo, Yanhua Guo, Peining Li, Junfeng Ban, Yan Zhang

Abstract read
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In one paragraph

Article in Current drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaru ZhouSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Xiangmei LiuCollaborative Innovation Center for NQI-Quality Safety of Guangzhou, Guangzhou Quality Supervision and Testing Institute, Guangzhou, 510006, China.
Tianyu TangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Jiawei LiangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Huashen HeSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Yingyao LuoSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Yanhua GuoCollaborative Innovation Center for NQI-Quality Safety of Guangzhou, Guangzhou Quality Supervision and Testing Institute, Guangzhou, 510006, China.
Peining LiCollaborative Innovation Center for NQI-Quality Safety of Guangzhou, Guangzhou Quality Supervision and Testing Institute, Guangzhou, 510006, China.
Junfeng BanSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Yan ZhangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.

Funding

Collaborative Innovation Center for NQI-Quality Safety of Guangzhou 2023B04J0407
6 · The paper itself

Abstract

introductionDifficulty in wound healing is a significant worldwide clinical challenge with serious health consequences and even life-threatening consequences. We designed an acrylic hydrogel loaded with metformin and investigated its mechanism of action in promoting wound repair.

methodsIn this study, we obtained self-assembled metformin hydrogels (SAMHs) delivery system using acrylic acid (AA) as matrix and ammonium persulfate (APS) as initiator, and evaluated the appearance, water vapor transmission rate, swelling properties, mechanical properties, and bioactivities of the SAMHs, and finally assessed the potential of the SAMHs for the treatment of chronic wounds in a diabetic rat wound model.

resultsSAMHs were colorless and transparent in appearance, with a water vapor transmission rate of 3530 g·m DISCUSSION: SAMHs exhibit excellent performance in several aspects, achieving slow drug release and promoting wound repair. In addition, SAMHs are simple and low-cost to prepare, which is expected to bring more cost-effective treatment options for diabetic patients. However, antimicrobial properties and clinical trial data are lacking in this study, and their applicability in complex wounds requires further validation.

conclusionThe hydrogel we prepared has excellent properties, is suitable for use in chronic wounds and promotes wound healing in diabetic rats and is an effective therapeutic strategy for chronic wounds.

Indexed as

Diabetes Mellitus, ExperimentalHydrogelsHypoglycemic AgentsMetforminWound HealingAcrylatesAmmonium SulfateAnimalsDrug LiberationMaleRatsRats, Sprague-DawleyAcrylatesacrylic acidAmmonium SulfateHydrogelsHypoglycemic AgentsMetforminangiogenesiscontrolled releasedelivery systemsdiabetic wound healinginflammationMetforminpolyacrylic acid hydrogel

Identifiers

PMID40734436

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.