ArticleInternational journal of urology : official journal of the Japanese Urological Association2025
Silicon-Based Agent Attenuates Age-Related Spermatogenesis Disorder.
Article in International journal of urology : official journal of the Japanese Urological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe progressive decline in birth rates due to delayed marriage has become a significant issue in developed countries, with male spermatogenetic capabilities gradually declining with age. This study evaluated the effectiveness of a silicon-based agent (Si-based) that efficiently generates hydrogen in the body to improve spermatogenic function in aged mice.
methodsEighty-five-week-old (aged) C57BL/6J mice were administered either a normal diet or a diet supplemented with a Si-based agent. Sperm analysis, histopathology, immunohistochemistry, immunofluorescence, and immunoblotting were performed to assess spermatogenic function, markers of oxidative stress, and activation of the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway.
resultsThe Si-based agent significantly increased sperm count and velocity (curvilinear and straight-line velocity), reduced the proportion of abnormal seminiferous tubules, and improved testicular histology in aged mice (p < 0.05). Furthermore, the Si-based agent decreased the expression of oxidative stress markers and modulated the KEAP1/NRF2 pathway by reducing the expression of KEAP1 and increasing NRF2 nuclear translocation, leading to the upregulation of the antioxidant genes-heme oxygenase (HMOX)-1 and NAD(P)H quinone oxidoreductase (NQO-1).
conclusionThese findings suggest that hydrogen delivered through a Si-based agent could be a promising therapeutic approach for age-related male infertility. This warrants further studies to explore its potential in clinical settings.
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