Evidence map›Paper›PMID 40734323›Full record

ArticleActa physiologica (Oxford, England)2025

Absence of Parkin Results in Atrophy of Oxidative Myofibers and Modulation of AKT and MURF1 Signaling in Middle-Aged Male Mice.

Isabela Aparecida Divino, Ana Laura da Vieira-da-Silva, Marcos Vinicius Esteca, Rafael Paschini Tonon, Felipe Oliveira Gomes da Cruz, Renata Rosseto Braga, Eduardo Rochete Ropelle, Paulo Guimarães Gandra, Igor Luchini Baptista

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In one paragraph

Article in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabela Aparecida DivinoLaboratory of Cell and Tissue Biology (LaBCeT), School of Applied Sciences, University of Campinas, Limeira, Brazil.
Ana Laura da Vieira-da-SilvaLaboratory of Cell and Tissue Biology (LaBCeT), School of Applied Sciences, University of Campinas, Limeira, Brazil.
Marcos Vinicius EstecaLaboratory of Cell and Tissue Biology (LaBCeT), School of Applied Sciences, University of Campinas, Limeira, Brazil.
Rafael Paschini TononLaboratory of Cell and Tissue Biology (LaBCeT), School of Applied Sciences, University of Campinas, Limeira, Brazil.
Felipe Oliveira Gomes da CruzLaboratory of Cell and Tissue Biology (LaBCeT), School of Applied Sciences, University of Campinas, Limeira, Brazil.
Renata Rosseto BragaLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, Brazil.
Eduardo Rochete RopelleLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, Brazil.
Paulo Guimarães GandraSkeletal Muscle Biology Laboratory, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Igor Luchini BaptistaLaboratory of Cell and Tissue Biology (LaBCeT), School of Applied Sciences, University of Campinas, Limeira, Brazil.ORCID https://orcid.org/0000-0001-5185-0185

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #403549/2021-3Conselho Nacional de Desenvolvimento Científico e Tecnológico #420265/2018-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo #2019/12236-5Fundação de Amparo à Pesquisa do Estado de São Paulo #2019/16891-8Fundação de Amparo à Pesquisa do Estado de São Paulo #2021/05588-2Fundação de Amparo à Pesquisa do Estado de São Paulo #2023/01903-6Fundação de Amparo à Pesquisa do Estado de São Paulo #2023/02076-6
6 · The paper itself

Abstract

aimThis work aimed to investigate the effects of the loss of Parkin in middle-aged mice skeletal muscle, focusing on different types of myofibers and in the analysis of proteins related to protein synthesis and degradation as well as the analysis of force generation and motor balance.

methodsWe used male mice C57BL/6J (WT) and Parkin knockout mice, Parkintm1Shn (Parkin

resultsThe Absence of Parkin in middle-aged mice leads to a reduction in isometric force generation but maintained overall motor and locomotion abilities, exhibited only minor balance deficits. In the SOL muscle of middle-aged Parkin

conclusionOur results suggest middle-aged Parkin

Indexed as

Muscle Fibers, SkeletalMuscle ProteinsMuscular AtrophyProto-Oncogene Proteins c-aktTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalSignal TransductionMuscle Proteinsparkin proteinProto-Oncogene Proteins c-aktTrim63 protein, mouseTripartite Motif ProteinsUbiquitin-Protein LigasesagingE3 ubiquitin ligasemuscle lossprotein synthesis signalingskeletal muscle

Identifiers

PMID40734323
PMCPMC12308108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.