Evidence map›Paper›PMID 40734318›Full record

Observational studyTherapeutic advances in respiratory disease

Azithromycin and oesophageal motility in chronic respiratory disease: a feasibility study.

Dominic L Sykes, Kayleigh Brindle, Rohan Menon, Simon P Hart, Jennifer Nielsen, Warren Jackson, John Gallagher, Elisabeth Kirton, Mengru Zhang, Alyn H Morice and 1 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05469555 (Exploring the Effect of Azithromycin on Oesophageal Motility and Respiratory Symptoms in Patients With Chronic Respiratory Disease), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05469555 completednot on this map

Exploring the Effect of Azithromycin on Oesophageal Motility and Respiratory Symptoms in Patients With Chronic Respiratory Disease: a Prospective Observational Study

TypeobservationalSponsorHull University Teaching Hospitals NHS TrustRan2023 to 2024Enrolled30ConditionsCough, Asthma, Copd, ILDArmsHigh Resolution Oesophageal Manometry
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dominic L SykesRespiratory Clinical Trials Unit, Hull York Medical School, Castle Hill Hospital, 1st Floor Daisy Building, Cottingham HU16 5JQ, UK Hull University Teaching Hospitals NHS Trust, Hull, UK.ORCID 0000-0002-0925-7772
Kayleigh BrindleRespiratory Research Group, Hull York Medical School, Cottingham, UK.
Rohan MenonRespiratory Research Group, Hull York Medical School, Cottingham, UK.
Simon P HartRespiratory Research Group, Hull York Medical School, Cottingham, UK.
Jennifer NielsenRespiratory Research Group, Hull York Medical School, Cottingham, UK.
Warren JacksonHull University Teaching Hospitals NHS Trust, Hull, UK.
John GallagherHull University Teaching Hospitals NHS Trust, Hull, UK.
Elisabeth KirtonHull University Teaching Hospitals NHS Trust, Hull, UK.
Mengru ZhangRespiratory Research Group, Hull York Medical School, Cottingham, UK.
Alyn H MoriceRespiratory Research Group, Hull York Medical School, Cottingham, UK.
Michael G CrooksRespiratory Research Group, Hull York Medical School, Cottingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of the gut-lung axis in respiratory disease is increasingly recognised. Much emphasis has been placed on gastro-oesophageal reflux disease; however, oesophageal dysmotility may also play a significant role. Azithromycin, a known prokinetic, has been shown to be of major benefit in a number of respiratory diseases, but the relationship between oesophageal function and the lung has not been examined.

objectivesWe assessed the feasibility of performing continuous cough monitoring and repeated high-resolution oesophageal manometry (HROM) in patients with chronic respiratory disease.

designWe conducted an open-label, single-arm, feasibility trial.

methodsAzithromycin 250 mg once daily was given to patients with chronic respiratory disease who reported a chronic cough. All participants were monitored continually for at least 1 week prior to and 4 weeks after azithromycin with the Hyfe Cough Tracker. Participants also had HROM performed at two time-points, immediately before and 4 weeks after initiation of azithromycin. Feasibility outcomes pertaining to recruitment, data quality, and acceptability of trial processes were assessed. Exploratory outcome data for metrics of oesophageal function were also analysed.

resultsA total of 30 participants (57% female, mean age 65.2 (SD = 11.3)) were recruited over a 10-month period, giving a recruitment rate of three patients per month in a single centre. A total of 87% (

conclusionA large-scale trial examining the effect of azithromycin on the relationship between oesophageal function and cough in respiratory disease is feasible and acceptable to patients.

trial registrationThis trial was prospectively registered ClinicalTrials.gov ID: NCT05469555.

Indexed as

Anti-Bacterial AgentsAzithromycinCoughEsophagusAgedChronic DiseaseFeasibility StudiesFemaleHumansMaleManometryMiddle AgedTime FactorsTreatment OutcomeAnti-Bacterial AgentsAzithromycinazithromycincoughgastro-oesophgaeal reflux

Identifiers

PMID40734318
PMCPMC12317180

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.