Evidence map›Paper›PMID 40734279›Full record

ArticleAdvanced healthcare materials2025

3D-Printed Multidimensional Bionic Mg-MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects.

Shihang Liu, Shuai Zhou, Tingting Zou, Guangzhao Hou, Qian Xiao, Lin Li, Jianjun Yang, Wei Chen, Yingze Zhang, Hongzhi Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shihang LiuDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.
Shuai ZhouDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.
Tingting ZouKey Laboratory of Biomechanics of Hebei Province, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Orthopaedic Research Institution of Hebei Province, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.
Guangzhao HouDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.
Qian XiaoDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.
Lin LiGPL Photonics Laboratory, Key Laboratory of Luminescence Science and Technology, Chinese Academy of Sciences & State Key Laboratory of Luminescence Science and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033, P. R. China.
Jianjun YangGPL Photonics Laboratory, Key Laboratory of Luminescence Science and Technology, Chinese Academy of Sciences & State Key Laboratory of Luminescence Science and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033, P. R. China.
Wei ChenDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.
Yingze ZhangDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.
Hongzhi LvDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P. R. China.ORCID 0000-0003-1616-6243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of long bone segmental defects represents a critical challenge in orthopedic medicine. This study focuses on developing an innovative bone repair material to overcome the inherent limitations of existing solutions. The material is synthesized by incorporating magnesium into mineralized collagen to produce Mg-MC bone powder, which is then combined with polylactic acid-hydroxyglycolic acid copolymer (PLGA). Using advanced 3D printing and femtosecond laser techniques, Mg-MC/PLGA scaffolds with varying magnesium concentrations (0%, 5%, 10%, 20%) are fabricated and characterized. In vitro studies demonstrate that the 5% Mg-MC/PLGA scaffold exhibits superior cytocompatibility, cellular proliferation, migration, angiogenesis, and osteogenic activity, supported by elevated expression of osteogenic markers. In vivo experiments in a rabbit model confirm the efficacy of the 5% Mg

Indexed as

Bone and BonesBone RegenerationLactic AcidMagnesiumPolyglycolic AcidPrinting, Three-DimensionalTissue ScaffoldsAnimalsBiocompatible MaterialsCell ProliferationHumansOsteogenesisPolylactic Acid-Polyglycolic Acid CopolymerRabbitsBiocompatible MaterialsLactic AcidMagnesiumPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymer3D printingbone defectsmagnesiummineralized collagenosteogenesis

Identifiers

PMID40734279
PMCPMC12616600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.