ArticleACS infectious diseases2025
Antimicrobial Peptides Can Facilitate Whole Blood Safety from Bacteria: A Proof of Concept.
Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Evaluation of protease resistant synthetic antimicrobial peptides as a new approach methodology to mitigate bacterial growth in ex vivo human platelet concentrates.Blood transfusion = Trasfusione del sangueArticle
- Evaluation of stored whole blood cellular components treated with bactericidal peptides at a higher concentration than required to assess the peptide compatibility with product quality.Blood transfusion = Trasfusione del sangueArticle
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Authors and funding
4 authors.
Funding
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Abstract
With continuous improvements to blood donor deferrals and the availability of sensitive tests for donation screening for infectious agents, bacterial contamination of whole blood (WB) and blood components stored for transfusion is a rare event. Nonetheless, it still occurs and remains a transfusion-associated risk in terms of septic transfusion reactions (STRs) and transfusion-transmitted bacterial infections with morbidity and mortality outcomes. One of the risk mitigation strategies for bacterial contamination is to implement treatment with currently available proactive pathogen reduction technologies (PRTs) for these transfusion products. Here, as a proof of concept, we tested two recently developed unique cationic antimicrobial peptides (AMPs; D-CONGA and D-CONGA-Q7) for WB safety from bacterial contamination. In this study, WB was inoculated with
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