Evidence map›Paper›PMID 40734243›Full record

ArticleEmerging microbes & infections2025

Vertical transmission of scrub typhus: a case report of congenital infection.

Yonghan Luo, Zhenghui Liao, Xianyao Yang, Hechun Li, Jinyu Chi, Zhifang Cha, Jun Liu, Chuangang Ding, Yue Feng

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yonghan LuoFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People's Republic of China.
Zhenghui LiaoPediatric Department, NO.1 people's hospital of Dali city, Dali, People's Republic of China.
Xianyao YangFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People's Republic of China.
Hechun LiPediatric Department, NO.1 people's hospital of Dali city, Dali, People's Republic of China.
Jinyu ChiClinical Laboratory, NO.1 people's hospital of Dali city, Dali, People's Republic of China.
Zhifang ChaPediatric Department, NO.1 people's hospital of Dali city, Dali, People's Republic of China.
Jun LiuImaging Department, NO.1 people's hospital of Dali city, Dali, People's Republic of China.
Chuangang DingPediatric Department, The First Affiliated Hospital of Dali University, Dali, People's Republic of China.
Yue FengFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scrub typhus (ST), caused by Orientia tsutsugamushi, is typically transmitted through mite bites, but vertical transmission from mother to infant remains poorly understood. This case presents a 13-day-old female neonate diagnosed with congenital ST. The infant developed severe systemic involvement, including fever, jaundice, respiratory distress, and signs of hemophagocytic lymphohistiocytosis (HLH). Despite broad-spectrum antibiotic therapy, her condition worsened. PCR and serological tests confirmed the diagnosis of ST in both the neonate and the mother, with IgM positivity indicating congenital infection. Following treatment with doxycycline, the patient's condition improved. This case adds to the growing body of evidence supporting the vertical transmission of ST and highlights the need for increased awareness of congenital ST.

Indexed as

Infectious Disease Transmission, VerticalOrientia tsutsugamushiScrub TyphusAnti-Bacterial AgentsDoxycyclineFemaleHumansImmunoglobulin MInfant, NewbornPregnancyAnti-Bacterial AgentsDoxycyclineImmunoglobulin MCongenital scrub typhusneonatal sepsisOrientia tsutsugamushisystematic reviewvertical transmission

Identifiers

PMID40734243
PMCPMC12337731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.