Evidence map›Paper›PMID 40733869›Full record

ArticleReports (MDPI)2023

A Rare Case of Malignant Ovarian Germ Cell Tumor: Dysgerminoma and Seminoma in the Same Patient.

Melinda-Ildiko Mitranovici, Diana Maria Chiorean, Sabin Gligore Turdean, Maria Cezara Mureșan, Corneliu-Florin Buicu, Raluca Moraru, Liviu Moraru, Titiana Cornelia Cotoi, Havva Serap Toru, Adrian Apostol and 5 more

Abstract readCase Reports
In one paragraph

Article in Reports (MDPI), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Melinda-Ildiko MitranoviciDepartment of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania.ORCID 0000-0003-1596-6353
Diana Maria ChioreanDepartment of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania.ORCID 0000-0002-7024-2916
Sabin Gligore TurdeanDepartment of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania.ORCID 0000-0001-7085-4755
Maria Cezara MureșanDepartment of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.
Corneliu-Florin BuicuPublic Health and Management Department, "George Emil Palade" University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.ORCID 0000-0002-7378-5756
Raluca MoraruFaculty of Medicine, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania.
Liviu MoraruDepartment of Anatomy, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania.
Titiana Cornelia CotoiDepartment of Pharmaceutical Technology, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania.
Havva Serap ToruDepartment of Pathology, Akdeniz University School of Medicine, Antalya Pınarbaşı, Konyaaltı, Antalya 07070, Turkey.ORCID 0000-0002-4438-0434
Adrian ApostolDepartment of Cardiology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.ORCID 0000-0001-6684-1759
Claudiu MărgineanDepartment of Obstetrics and Gynecology, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania.
Ion PetreDepartment of Medical Informatics and Biostatistics, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.
Ioan Emilian OalăDepartment of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania.
Viviana IvanDepartment of Cardiology, "Pius Brinzeu" County Hospital, 2 Eftimie Murgu Sq, 300041 Timisoara, Romania.
Ovidiu Simion CotoiDepartment of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian malignant germ cell tumors (OMGCTs) represent a rare type of malignant tumors composed of primitive germ cells that often originate from dysgenetic gonads and are frequently associated with hermaphroditism. Such tumors occur more frequently in adolescents or young adults, and their etiopathogenic mechanism is not well established. We report the case of a 20-year-old female with ovarian dysgenesis and female phenotype. A laparoscopic surgery was performed, and ovotestis was discovered. To achieve a histopathological examination, right oophorectomy was performed, which confirmed the diagnosis of dysgerminoma. In the case of hermaphroditism, mixed germ cell tumors can develop, leading to a more aggressive evolution with bilateral malignancy of the gonads, which requires the removal of both ovotestis. The patient was recalled. A histopathological examination revealed a seminoma, so laparoscopic left oophorectomy was performed. The management of this type of diagnosis primarily involves surgery, minimally invasive interventions being preferred. Not all pathologic conditions are readily identifiable by means of exploratory laparoscopy, as in our patient's case. We consider that the optimal solution for these patients would be the preservation of fertility via egg donation and embryo transfer; the survival rate of such patients being 97-100%, if the tumor is diagnosed at an early age.

Indexed as

dysgenetic gonadsdysgerminomaegg donationembryo transferhermaphroditismoophorectomyseminoma

Identifiers

PMID40733869
PMCPMC12225335

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.