Evidence map›Paper›PMID 40733735›Full record

ArticleVaccines2025

XBB.1.5 COVID-19 mRNA Vaccines Induce Inadequate Mucosal Immunity in Patients with Inflammatory Bowel Disease.

Simon Woelfel, Joel Dütschler, Daniel Junker, Marius König, Georg Leinenkugel, Claudia Krieger, Samuel Truniger, Annett Franke, Seraina Koller, Katline Metzger-Peter and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Simon WoelfelDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.ORCID 0000-0003-2528-0582
Joel DütschlerDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Daniel JunkerNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.
Marius KönigDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Georg LeinenkugelDepartment of Gastroenterology and Hepatology, University Digestive Healthcare Center, Clarunis, 4002 Basel, Switzerland.
Claudia KriegerDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.ORCID 0000-0002-7949-0385
Samuel TrunigerDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Annett FrankeDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Seraina KollerDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Katline Metzger-PeterDepartment of Gastroenterology and Hepatology, University Digestive Healthcare Center, Clarunis, 4002 Basel, Switzerland.ORCID 0009-0000-3133-0887
Nicola FreiDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.ORCID 0000-0002-5358-2767
Star Sign Study Investigators
Werner C AlbrichDivision of Infectious Diseases, Infection Prevention & Travel Medicine, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Matthias FriedrichTranslational Gastroenterology and Liver Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Jan Hendrik NiessDepartment of Gastroenterology and Hepatology, University Digestive Healthcare Center, Clarunis, 4002 Basel, Switzerland.ORCID 0000-0001-6902-5650
Nicole Schneiderhan-MarraNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.ORCID 0000-0001-6785-181X
Alex DulovicNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.
Wolfgang KorteCenter for Laboratory Medicine, 9001 St. Gallen, Switzerland.
Justus J BürgiCenter for Laboratory Medicine, 9001 St. Gallen, Switzerland.
Stephan BrandDepartment of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.

Funding

Cantonal Hospital St. Gallen 23/26HORIZON Europe European Research Council 101003480-CORESMAState Ministry of Baden-Württemberg for Economic Affairs, Labor, and Tourism FKZ-3-4332.62-NMI-67 and FKZ 3-4332.62-NMI-68University of Oxford NA
6 · The paper itself

Abstract

backgroundMucosal immunity plays a pivotal role in preventing infections with SARS-CoV-2. While COVID-19 mRNA vaccines induce robust systemic immune responses in patients with inflammatory bowel disease (IBD), little is known about their efficacy in the mucosal immune compartment. In this sub-investigation of the ongoing STAR-SIGN study, we present the first analysis of mucosal immunity elicited by XBB.1.5 mRNA vaccines in immunocompromised patients with IBD.

methodsIgG and IgA antibodies targeting the receptor-binding domain of the SARS-CoV-2 JN.1 variant were quantified longitudinally in the saliva of IBD patients using the multiplex immunoassay MultiCoV-Ab. Antibody levels were quantified before and 2-4 weeks after vaccination with XBB.1.5 mRNA vaccines. All patients previously received three doses with original COVID-19 vaccines.

resultsMucosal IgG antibodies were readily induced by XBB.1.5 mRNA vaccines (

conclusionsSince mucosal IgA plays a pivotal role in infection control, the lack of IgA induction indicates that patients lack sufficient protection against SARS-CoV-2 infections which warrants the development of mucosal COVID-19 vaccines.

Indexed as

anti-TNFCOVID-19IgAinflammatory bowel diseaseJN.1mRNA vaccinesmucosal immunitySARS-CoV-2XBB.1.5

Identifiers

PMID40733735
PMCPMC12300279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.