Evidence map›Paper›PMID 40733669›Full record

ReviewVaccines2025

Advances in Contraceptive Vaccine Development: A Comprehensive Review.

Wen Gao, Xiaoting Shen, Peipei Li, Chanchan Xiao, Yongxia Wang

Abstract readReview
In one paragraph

Review in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wen GaoNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, China.ORCID 0000-0003-0085-8659
Xiaoting ShenNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, China.
Peipei LiNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, China.
Chanchan XiaoThe Affiliated Hospital of Xiangnan University, Chenzhou 423000, China.
Yongxia WangNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The issues of uncontrolled global population growth and unintended pregnancies are severe, and the existing contraceptive methods have numerous limitations, making the development of novel contraceptive technologies urgent. Contraceptive vaccines offer a promising alternative to traditional contraception methods. This article reviews the three developmental stages of contraceptive vaccines, including early exploration, technical bottlenecks, and innovative development directions in the new era. This article also summarizes the targets of immunocontraception, covering the current research status of contraceptive vaccines targeting sperm production, sperm antigens, oocyte zona pellucida, and gamete outcomes. Furthermore, this article explores the advantages of contraceptive vaccines in terms of efficiency, non-invasiveness, reversibility, and the promotion of gender equality. Challenges associated with clinical translation and real-world implementation are also critically analyzed.

Indexed as

contraceptive vaccinesgamete outcomesimmunocontraceptionsperm antigenssperm productionzona pellucida of oocytes

Identifiers

PMID40733669
PMCPMC12299859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.