Evidence map›Paper›PMID 40733631›Full record

ArticleViruses2025

Rift Valley Fever Outbreak Investigation Associated with a Dairy Farm Abortion Storm, Mbarara District, Western Uganda, 2023.

Luke Nyakarahuka, Shannon Whitmer, Sophia Mulei, Joanita Mutesi, Jimmy Baluku, Jackson Kyondo, Amy Whitesell, Carson Telford, Alex Tumusiime, Calvin Richie Torach and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Luke NyakarahukaUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.ORCID 0000-0002-2944-9157
Shannon WhitmerUS Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA.
Sophia MuleiUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Joanita MutesiUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Jimmy BalukuUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Jackson KyondoUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Amy WhitesellUS Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA.
Carson TelfordUS Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA.
Alex TumusiimeUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Calvin Richie TorachUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Dianah NamanyaUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Mariam NambuyaMinistry of Health of Uganda, Kampala P.O. Box 7272, Uganda.
Dominic MuherezaMbarara Regional Referral Hospital, Mbarara P.O. Box 40, Uganda.
Zainah KabamiPublic Health Fellowship Program, Uganda National Institute of Public Health, Kampala P.O. Box 7272, Uganda.ORCID 0009-0009-3416-4111
Annet NankyaPublic Health Fellowship Program, Uganda National Institute of Public Health, Kampala P.O. Box 7272, Uganda.
David MuwanguziMinistry of Health of Uganda, Kampala P.O. Box 7272, Uganda.
Francis MugabiMbarara Regional Referral Hospital, Mbarara P.O. Box 40, Uganda.
Nelson WanderaMbarara Regional Referral Hospital, Mbarara P.O. Box 40, Uganda.
Rose MuhindoDepartment of Internal Medicine, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara P.O. Box 1410, Uganda.
Joel M MontgomeryUS Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA.
Julius J LutwamaUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
Stephen Karabyo BalinandiUganda Virus Research Institute, Entebbe P.O. Box 49, Uganda.
John D KlenaUS Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA.ORCID 0000-0001-9933-6193
Trevor R ShoemakerUS Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA.

Funding

CDC HHS RFA-CK-13-001.
6 · The paper itself

Abstract

In Africa, Rift Valley Fever poses a substantial risk to animal health, and human cases occur after contact with infected animals or their tissues. RVF has re-emerged in Uganda after nearly five decades, with multiple outbreaks recorded since 2016. We investigated a unique RVF outbreak associated with an animal abortion storm of 30 events and human cases on a dairy farm in Mbarara District, Western Uganda, in February 2023. Genomic analysis was performed, comparing animal and human RVF viruses (RVFV) circulating in the region. A cluster of thirteen human RVF cases and nine PCR-positive animals could directly be linked with the abortion storm. Overall, during the year 2023, we confirmed 61 human RVFV cases across Uganda, 88.5% of which were reported to have had direct contact with livestock, and a high case fatality rate of 31%. We recommend implementing extensive health education programs in affected communities and using sustainable mosquito control strategies to limit transmission in livestock, coupled with initiating animal vaccination trials in Uganda.

Indexed as

Abortion, VeterinaryDisease OutbreaksRift Valley FeverRift Valley fever virusAdultAnimalsCattleCattle DiseasesDairyingFarmsFemaleHumansLivestockPhylogenyPregnancyUgandaanimal abortion stormshuman RVF outbreaklivestock–human interfaceRift Valley FeverRVF virusvaccination trialswestern Ugandazoonotic transmission

Identifiers

PMID40733631
PMCPMC12298680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.