Evidence map›Paper›PMID 40733612›Full record

Observational studyViruses2025

Soluble Neuropilin-1 as a Marker for Distinguishing Bacterial and Viral Sepsis in Critically Ill Patients-A Prospective, Multicenter, Observational Study.

Fabian Perschinka, Georg Franz Lehner, Timo Mayerhöfer, Frank Hartig, Birgit Zassler, Johannes Bösch, Dietmar Fries, Romuald Bellmann, Michael Joannidis

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fabian PerschinkaDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0677-8756
Georg Franz LehnerDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.
Timo MayerhöferDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-7645-1252
Frank HartigDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2835-5263
Birgit ZasslerDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0009-0007-3010-1055
Johannes BöschDepartment of General and Surgical Intensive Care Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0152-0975
Dietmar FriesDepartment of General and Surgical Intensive Care Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-1225-4214
Romuald BellmannDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-2861-3258
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-6996-0881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis causes millions of deaths each year. Rapid, targeted therapy can reduce mortality rates. Both bacterial and viral pathogens can trigger sepsis, but the utility of commonly used inflammatory markers for differentiation remains controversial. Moreover, little is known about the time courses of alternative inflammatory parameters. The aim of this prospective, two-center observational study was to investigate the differences in the course of soluble Neuropilin-1 (sNRP-1) levels between bacterial and viral sepsis over a 7-day period. To be included, adult patients had to meet the SEPSIS-3 criteria and be diagnosed with either a bacterial or viral pathogen. Immunosuppressed patients were excluded. While IL-6, PCT, and CRP levels decreased consistently over time, sNRP-1 levels remained elevated in the bacterial group throughout the entire ICU stay. PCT (

Indexed as

Bacterial InfectionsBiomarkersNeuropilin-1SepsisVirus DiseasesAdultAgedC-Reactive ProteinCritical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesBiomarkersC-Reactive ProteinNeuropilin-1bacterial infectioncritically illinflammationsepsissoluble Neuropilin-1viral infection

Identifiers

PMID40733612
PMCPMC12297973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.