Evidence map›Paper›PMID 40733606›Full record

ArticleViruses2025

Entry Inhibitors of SARS-CoV-2 Targeting the Transmembrane Domain of the Spike Protein.

Kristin V Lyles, Shannon Stone, Priti Singh, Lila D Patterson, Janhavi Natekar, Heather Pathak, Rohit K Varshnaya, Amany Elsharkawy, Dongning Liu, Shubham Bansal and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kristin V LylesDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.ORCID 0000-0003-0395-673X
Shannon StoneDepartment of Biology, Georgia State University, Atlanta, GA 35302, USA.ORCID 0000-0003-2314-3437
Priti SinghDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.
Lila D PattersonDepartment of Biology, Georgia State University, Atlanta, GA 35302, USA.ORCID 0009-0009-2502-5793
Janhavi NatekarDepartment of Biology, Georgia State University, Atlanta, GA 35302, USA.
Heather PathakDepartment of Biology, Georgia State University, Atlanta, GA 35302, USA.
Rohit K VarshnayaDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.
Amany ElsharkawyDepartment of Biology, Georgia State University, Atlanta, GA 35302, USA.ORCID 0009-0003-3645-5605
Dongning LiuDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.ORCID 0009-0008-0505-6851
Shubham BansalDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.ORCID 0000-0003-3603-5099
Oluwafoyinsola O FaniyiDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.
Sijia TangDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.
Xiaoxiao YangDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.
Nagaraju MulpuriDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.
Donald HamelbergDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.
Congbao KangExperimental Drug Development Centre (EDDC), Agency for Science, Technology, and Research (A*STAR), Singapore 138634, Singapore.ORCID 0000-0002-9886-9374
Binghe WangDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.ORCID 0000-0002-2200-5270
Mukesh KumarDepartment of Biology, Georgia State University, Atlanta, GA 35302, USA.ORCID 0000-0003-0970-4875
Ming LuoDepartment of Chemistry, Georgia State University, Atlanta, GA 35302, USA.ORCID 0000-0003-1766-3487

Funding

Project 5: Pandemic Virus Helicase InhibitorsU19AI171954 · NIAID · UNIVERSITY OF MINNESOTA · PI Donghoon Chung · 2022 to 2026
$100.9M
Developing computational tools to complement experiments in understanding biomolecular function from conformational ensemblesR35GM153718 · NIGMS · GEORGIA STATE UNIVERSITY · PI Donald Hamelberg · 2024 to 2026
$1.2M
NIAID NIH HHS U19 AI171954NIGMS NIH HHS R35 GM153718NIH HHS 1R35GM153718-05NIH HHS 1U19AI171954-02
6 · The paper itself

Abstract

Despite current vaccines and therapeutics targeting SARS-CoV-2, the causative agent of the COVID-19 pandemic, cases remain high causing a burden on health care systems. Spike-protein mediated membrane fusion of SARS-CoV-2 is a critical step in viral entry. Herein, we describe entry inhibitors identified by first screening a library of about 160 compounds and then analogue synthesis. Specifically, compound

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentSARS-CoV-2Spike Glycoprotein, CoronavirusVirus InternalizationAnimalsBinding SitesChlorocebus aethiopsCOVID-19HumansMolecular Dynamics SimulationProtein BindingProtein DomainsVero CellsAntiviral AgentsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antiviralcoronavirusentry inhibitorpan-coronavirusspike proteintransmembrane domain

Identifiers

PMID40733606
PMCPMC12300635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.