Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jenna M HassonHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Mary Grace KatusiimeHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Adam A CapoferriHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-6048-2115
Michael J BaleHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-6899-1459
Brian T LukeFrederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.ORCID 0000-0002-2777-7376
Wei ShaoFrederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Mark F CottonDivision of Medical Virology, Department of Pathology, Stellenbosch University, Cape Town 7500, South Africa.ORCID 0000-0003-2559-6034
Gert van ZylDivision of Medical Virology, Department of Pathology, Stellenbosch University, Cape Town 7500, South Africa.ORCID 0000-0003-3021-5101
Sean C PatroFrederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.ORCID 0000-0001-7550-6047
Mary F KearneyHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0003-3839-6576
Funding
Structural Biology CoreU54AI170855 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Bruce Edward Torbett · 2022 to 2026
$36.7M
Characterizing HIV-1 diversity, evolution, and integration sites in children initiating cART in early infectionU01CA200441 · NCI · STELLENBOSCH UNIVERSITY · PI KEARNEY, MARY, VAN ZYL, GERT UVES · 2015 to 2019
$842k
PHASE I THERAPEUTIC AWARD: CHIMERIC NANOPARTICLE DELIVERY OF AN SARNA-BASED CANCER VACCINE FOR FAMILIAL ADENOMATOUS POLYPOSIS75N91024C00011 · NCI · CHIMERON BIO CORPORATION · PI SIMMONS, ALFRED · 2024 to 2024
$300k
Intramural National Cancer Institute ZIA BC 011697National Institutes of Allergy and Infectious Diseases (Comprehensive International Program for Research on AIDS [CIPRA]-South Africa U19 AI153217NCI NIH HHS 75N91024C00011NCI NIH HHS U01 CA200441NIAID NIH HHS U54 AI170855U.S.-South Africa Program for Collaborative Biomedical Research; the National Cancer Institute U01CA200441
6 · The paper itself
Abstract
HIV-1 proviral landscapes were investigated using near-full-length HIV single-genome sequencing on blood samples from five children with vertically acquired infection and on ART for ~7-9 years. Proviral structures were compared to published datasets in children prior to ART, children on short-term ART, and adults on ART. We found a strong selection for large internal proviral deletions in children, especially deletions of the
Indexed as
Anti-Retroviral AgentsHIV-1HIV InfectionsProvirusesAdultChildChild, Preschoolenv Gene Products, Human Immunodeficiency VirusFemaleGenome, ViralHumansMaleAnti-Retroviral Agentsenv Gene Products, Human Immunodeficiency VirusHIV in childrenHIV latencyHIV persistenceHIV provirusesHIV reservoirintact provirus
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy. · full record | OpenQuestion