Evidence map›Paper›PMID 40733533›Full record

ArticleViruses2025

Immune and Safety Analysis of

David A MacLeod, John K Tobin, Ruth V Bushnell, Taralyn J Wiggins, Shyamkumar Ts, Ramchander Nadipelly, Steven Lawson, Viju V Pillai, Gregory J Tobin, Stephen J Dollery

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David A MacLeodBiological Mimetics, Inc., Frederick, MD 21702, USA.
John K TobinBiological Mimetics, Inc., Frederick, MD 21702, USA.
Ruth V BushnellBiological Mimetics, Inc., Frederick, MD 21702, USA.
Taralyn J WigginsBiological Mimetics, Inc., Frederick, MD 21702, USA.
Shyamkumar TsDepartment of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.
Ramchander NadipellyDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA.
Steven LawsonDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA.
Viju V PillaiDepartment of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.
Gregory J TobinBiological Mimetics, Inc., Frederick, MD 21702, USA.ORCID 0000-0002-8396-0466
Stephen J DolleryBiological Mimetics, Inc., Frederick, MD 21702, USA.ORCID 0000-0002-1712-3811

Funding

Nonclinical Development of an Improved Polio VaccineR44AI120260 · NIAID · BIOLOGICAL MIMETICS, INC. · PI TOBIN, GREGORY JOHN · 2017 to 2024
$4.4M
NIAID NIH HHS R44 AI120260NIH HHS 2R44AI120260-24
6 · The paper itself

Abstract

The eradication of poliovirus remains a global health priority, with inactivated polio vaccines (IPVs) playing a pivotal role in immunization strategies. Over the past decades, advancements in IPV production have focused on optimizing safety, efficacy, and immunogenicity while addressing vaccine production and logistical challenges. This paper discusses a novel IPV candidate,

Indexed as

PoliomyelitisPoliovirusPoliovirus Vaccine, InactivatedUltraviolet RaysAnimalsAntibodies, NeutralizingAntibodies, ViralFemaleImmunogenicity, VaccineMaleRatsRats, WistarVirus InactivationAntibodies, NeutralizingAntibodies, ViralPoliovirus Vaccine, InactivatedIPOLIPVpolio vaccineultraIPVUVC-inactivated polio vaccineUVC irradiationUV inactivation

Identifiers

PMID40733533
PMCPMC12300962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.