SynthesisViruses2025
Trends in the Mortality, Deaths, and Aetiologies of Lower Respiratory Infections Among 204 Countries from 1991 to 2021: An Updated Systematic Study.
Synthesis in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Complete Blood Count-Derived Inflammatory Markers in Pediatric Lower Respiratory Tract Infection: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Review
- Target-Based Antiviral Drug Development Against Human Respiratory Viruses.Pathogens (Basel, Switzerland) · 2026Review
- Nanotechnology-Enabled Strategies to Overcome Antibiotic Resistance in Respiratory Infections: Mechanisms, Platforms, and Translational Challenges.Biomedicines · 2026Review
- Phospholipase A2 Isoforms in Lung Immunity and Respiratory Infections: Potential Targets for Next-Generation Therapy.International journal of molecular sciences · 2026Review
- The global burden of lower respiratory infections attributable to smoking and secondhand smoke, 1990-2021, with projections to 2050: a systematic analysis of the GBD 2021 study.Journal of health, population, and nutrition · 2026Article
- Nanodrug Delivery Systems for Lower Respiratory Infections: Pulmonary Targeting, Anti-Infective Applications, and Translational Challenges.International journal of nanomedicine · 2026Review
- Analysis of bacterial pathogen spectrum and epidemiological characteristics of pediatric lower respiratory tract infections: a large sample study based on bronchoalveolar lavage.BMC infectious diseases · 2025Article
- Burden of lower respiratory infections in five East Asian countries from 1990 to 2021: observation, comparison, and forecast from the global burden of disease study 2021.Frontiers in public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Lower respiratory infections (LRIs) persist as a major global health threat. This study analyses the 1991-2021 trends in LRI mortality, deaths, and aetiologies across 204 countries using Global Burden of Disease 2021 data, aiming to evaluate the disease burden of LRIs and provide evidence-based guidance for prevention strategies. To quantify the temporal trends, the annual percentage change was estimated (EAPC) using linear regression modeling. Globally, the ASMR for LRI decreased by an average of 2.29% annually (95% CI: 2.16-2.42%). While ASMR decreased in 20 of the GBD regions, mortality rates in Southern Latin America increased (EAPC = 1.32, 95% CI: 0.98-1.67). The LRI burden remains the heaviest in low SDI regions and sub-Saharan Africa. LRIs continue to cause high mortality in children and the elderly. Mortality in children decreased rapidly, while mortality in the elderly declined more slowly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.