Evidence map›Paper›PMID 40733301›Full record

ArticleMolecules (Basel, Switzerland)2025

Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery.

Francesca Paoletti, Tjaša Goričan, Alberto Cassetta, Jože Grdadolnik, Mykola Toporash, Doriano Lamba, Simona Golič Grdadolnik, Sonia Covaceuszach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca PaolettiInstitute of Crystallography-C.N.R.-Trieste Outstation, 34149 Trieste, Italy.
Tjaša GoričanLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, 1001 Ljubljana, Slovenia.ORCID 0009-0000-7736-7941
Alberto CassettaInstitute of Crystallography-C.N.R.-Trieste Outstation, 34149 Trieste, Italy.ORCID 0000-0002-8600-4162
Jože GrdadolnikLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, 1001 Ljubljana, Slovenia.ORCID 0000-0002-0312-168X
Mykola ToporashInstitute of Crystallography-C.N.R.-Trieste Outstation, 34149 Trieste, Italy.
Doriano LambaInstitute of Crystallography-C.N.R.-Trieste Outstation, 34149 Trieste, Italy.ORCID 0000-0001-6859-7868
Simona Golič GrdadolnikLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, 1001 Ljubljana, Slovenia.ORCID 0000-0002-0873-9593
Sonia CovaceuszachInstitute of Crystallography-C.N.R.-Trieste Outstation, 34149 Trieste, Italy.

Funding

ARIS J1-4400ARIS P1-0010CERIC-ERIC 20232078Next Generation EU IR0000028
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Dimethyl SulfoxideDrug DiscoveryNerve Growth FactorSolventsHumansProtein BindingSpectroscopy, Fourier Transform InfraredDimethyl SulfoxideNerve Growth FactorNGF protein, humanSolventsDifferential Scanning Fluorimetry (DSF)dimethyl sulfoxide (DMSO)drug discoveryFourier Transform Infrared (FT-IR) spectroscopyGrating-Coupled Interferometry (GCI)HADDOCKNerve Growth Factor (NGF)Nuclear Magnetic Resonance (NMR)Protenixsolvent effect

Identifiers

PMID40733301
PMCPMC12300743

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.