ArticleMolecules (Basel, Switzerland)2025
Design and Synthesis of Boronic Chalcones with Dual Anticancer and Anti-Inflammatory Activity.
Juliana Romano Lopes, Freddy Humberto Marin-Dett, Rita Alexandra Machado Silva, Rafael Consolin Chelucci, Lucília Saraiva, Maria Emília Sousa, Leonardo Luiz Gomes Ferreira, Adriano Defini Andricopulo, Paula Aboud Barbugli, Jean Leandro Dos Santos
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Juliana Romano LopesSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil.ORCID 0000-0002-3141-501X Freddy Humberto Marin-DettSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil.ORCID 0000-0002-6979-625X Rita Alexandra Machado SilvaLAQV/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.ORCID 0009-0006-9328-8171 Rafael Consolin ChelucciLaboratory of Medicinal and Computational Chemistry, Physics Institute of São Carlos, University of São Paulo (USP), São Carlos 13563-120, SP, Brazil.
Lucília SaraivaLAQV/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-9531-4939 Maria Emília SousaLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-5397-4672 Leonardo Luiz Gomes FerreiraLaboratory of Medicinal and Computational Chemistry, Physics Institute of São Carlos, University of São Paulo (USP), São Carlos 13563-120, SP, Brazil.ORCID 0000-0002-6947-0639 Adriano Defini AndricopuloLaboratory of Medicinal and Computational Chemistry, Physics Institute of São Carlos, University of São Paulo (USP), São Carlos 13563-120, SP, Brazil.ORCID 0000-0002-0457-818X Paula Aboud BarbugliSchool of Dentistry, São Paulo State University (UNESP), Araraquara 14801-385, SP, Brazil.
Jean Leandro Dos SantosSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil.ORCID 0000-0002-2460-2829 Funding
CAPES 88887.503193/2020-00CAPES/PRINT 88887.916247/2023-00FAPESP 13/07600-3FAPESP 2019/07574-9FAPESP 2023/05739-6
6 · The paper itselfAbstract
Head and neck cancer (HNC) is a highly aggressive malignancy with limited treatment options and poor prognosis. Inflammation plays a critical role in HNC progression, with elevated levels of pro-inflammatory cytokines such as TNF, IL-6, IL-8, and IL-1β contributing to tumor development. In this study, a novel series of boronic chalcones was designed and synthesized as potential dual-action anticancer and anti-inflammatory agents. The most potent compounds were evaluated for their cytotoxicity against Squamous Cell Carcinoma (SCC-25), and their selectivity index (SI) was determined. Compound
Indexed as
Anti-Inflammatory AgentsAntineoplastic AgentsBoronic AcidsChalconesDrug DesignCell Line, TumorCytokinesHumansStructure-Activity RelationshipAnti-Inflammatory AgentsAntineoplastic AgentsBoronic AcidsChalconesCytokinesanti-inflammatoryboronic acidchalconeshead and neck cancer
Identifiers
PMID40733296
PMCPMC12301034
What OpenQuestion holds
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LicenceCC BY
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