ReviewMolecules (Basel, Switzerland)2025
The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design.
Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Computer-aided molecular engineering of novel imidazolone-chalcone conjugates as antidiabetic agent: synthesis, molecular docking, DFT study, enzyme kinetics and ADME profiling.Journal of computer-aided molecular design · 2026Article
- Expanding the Medicinal Chemistry Toolbox for PET Imaging: AliphaticChemical & biomedical imaging · 2026Article
- A Proline-Based 'Redox-Release' Platform for Programmed Access to Diverse Sulfur(VI) and Fluoroalkyl Radicals.Research square · 2026Article
- Design, synthesis, and evaluation of pyrano[3,2-RSC advances · 2026Article
- Evaluation of Pyrazolone-Based Hydrazones as Potential Therapeutic Agents Against Glioblastoma.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Fluorinated Chromone Derivatives: Synthesis, Theoretical Study, and Evaluation of Their Biological Potential.ACS omega · 2026Article
- Recent progress in the direct monofluoromethylation of C-H bonds.RSC advances · 2026Review
- Activation of the Aryl Hydrocarbon Receptor-Cytochrome P450 1A1 Axis Mediates the Selective Cytotoxicity of 2‑Phenyl-Imidazo[1,2‑ACS pharmacology & translational science · 2026Article
- Green synthesis of tetrahydropyridine-3-carboxylate derivatives and evaluation of antimicrobial and antimalarial activities supported by molecular docking, POM studies, and drug-likeness analysis.Scientific reports · 2026Article
- Total Synthesis of Piperine and Derivatives: Antimicrobial and Cytotoxic Activities.ACS omega · 2026Article
- Distinct 2-phenylimidazo[1,2-iScience · 2026Article
- Novel pyridine-based chalcone analogs and triple negative breast cancer: potential therapy & molecular pathways.Scientific reports · 2026Article
- Rega: A Platform for the Prediction of the Regioselectivity of C-H Functionalization Reactions.Journal of chemical information and modeling · 2026Article
- Trends in Organofluorine Chemistry Reveal Gaps in Knowledge on Environmental Persistence.Environmental science & technology · 2026Review
- Article
- Lead Optimization: Synthesis and Biological Evaluation of Griseofulvin Derivatives as Novel SIRT6 Activators.ACS medicinal chemistry letters · 2026Article
- Synthesis of Some Novel Chalcone and 3,5-Disubstituted Pyrazoline Derivatives: Evaluation of Their α-Amylase and α-Glucosidase Inhibitory Activities In Vitro and In Silico.Archiv der Pharmazie · 2026Article
- Deoxyfluorination of Hydroxy-Substituted Boronates.ACS organic & inorganic Au · 2026Article
- Article
- Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions.Beilstein journal of organic chemistry · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the key strategies in drug design involves modifying molecular scaffolds with specific chemical groups, or side chains, to enhance biological and physicochemical properties. These modifications can strengthen interactions with biological targets or improve pharmacokinetic and physicochemical characteristics, factors that are critical in transforming a compound into a viable drug candidate. In this overview, we focus on the presence of trifluoromethyl and trifluoromethoxy groups on different molecules, highlighting their relevance and impact in medicinal chemistry. The discussion and future perspectives in the field are based on a comprehensive review of current literature, with data sourced mainly from SciFinder and PubMed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.