Evidence map›Paper›PMID 40733240›Full record

ArticleMolecules (Basel, Switzerland)2025

Extended Antimicrobial Profile of Chromone-Butenafine Hybrids.

Francesca Bonvicini, Lisa Menegaldo, Rebecca Orioli, Federica Belluti, Giovanna Angela Gentilomi, Silvia Gobbi, Alessandra Bisi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesca BonviciniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.ORCID 0000-0001-8101-9835
Lisa MenegaldoDepartment of Chemistry "G. Ciamician", Alma Mater Studiorum-University of Bologna, Via Gobetti 85, 40129 Bologna, Italy.
Rebecca OrioliDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Federica BellutiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.ORCID 0000-0002-6365-5579
Giovanna Angela GentilomiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Silvia GobbiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.ORCID 0000-0001-9044-5377
Alessandra BisiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.ORCID 0000-0003-4662-4743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal infections are recognized as a global health issue, in particular considering the spread of different forms of resistance to the commonly used antifungal drugs and their involvement in the occurrence of co-infections in hospitalized and immunocompromised patients. In this paper, a small series of hybrid compounds were designed and synthesized by linking the privileged chromone and xanthone scaffolds, endowed with recognized antimicrobial potential, to the tert-butylbenzylamino portion of the antifungal drug butenafine, through selected linkers. The results showed for the xanthone-based compound

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsChromonesCandidaHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipXanthonesAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsChromonesXanthonesantimicrobial propertiesbutenafinechromonecytotoxicityhemolytic activity

Identifiers

PMID40733240
PMCPMC12300761

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.