Death of Leukemia Cells and Platelets Induced by 3,3'-Dihydroxy-4,5-Dimethoxybibenzyl Is Mediated by p38 Mitogen-Activated Protein Kinase Pathway.

Natalia Rukoyatkina, Tatyana Sokolova, Nikita Pronin, Andrei Whaley, Anastasiia O Whaley, Stepan Gambaryan

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Advances in Natural Products and Their Biological Activities.Molecules (Basel, Switzerland) · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia RukoyatkinaSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg 194223, Russia.ORCID 0000-0002-3920-206X

Tatyana SokolovaSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg 194223, Russia.ORCID 0000-0001-9642-6388

Nikita ProninSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg 194223, Russia.ORCID 0000-0002-5360-1825

Andrei WhaleyDepartment of Pharmacognosy, Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg 197022, Russia.ORCID 0000-0002-4847-5924

Anastasiia O WhaleyDepartment of Pharmacognosy, Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg 197022, Russia.ORCID 0000-0003-4879-9336

Stepan GambaryanSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg 194223, Russia.ORCID 0000-0002-1470-0791

Funding

Russian Science Foundation 23-15-00142

6 · The paper itself

Abstract

Bibenzyls are now recognized as compounds for use in cancer therapy, and many molecules from the bibenzyl group have shown promising anticancer activity; therefore, the characterization of new bibenzyls with strong biological activity is important for developing new anticancer drugs. In this study, we compared the effects of three bibenzyls (3,3'-dihydroxy-4,5-dimethoxybibenzyl, 3,5-dihydroxy-4-methoxybibenzyl and 3,5,3'-trihydroxy-4-methoxybibenzyl) isolated from

Indexed as

BibenzylsBlood PlateletsLeukemiaMAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesApoptosisCell Line, TumorCell SurvivalHumansBibenzylsp38 Mitogen-Activated Protein Kinasesbibenzylscyclic adenosine monophosphate (cAMP)cyclic guanosine monophosphate (cGMP)MOLT-3 cellsp38 mitogen-activated protein kinase (p38 MAPK)plateletsprotein kinase A (PKA)protein kinase G (PKG)

Identifiers

PMID40733232

DOI10.3390/molecules30142965

PMCPMC12300253

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