Environmental Antidepressants Disrupt Metabolic Pathways in

Artur Jędreas, Sylwia Michorowska, Agata Drobniewska, Joanna Giebułtowicz

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Artur JędreasDepartment of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Medical University of Warsaw, 02-091 Warszawa, Poland.

Sylwia MichorowskaDepartment of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Medical University of Warsaw, 02-091 Warszawa, Poland.ORCID 0000-0001-7079-7527

Agata DrobniewskaDepartment of Toxicology and Food Science, Medical University of Warsaw, 02-091 Warszawa, Poland.ORCID 0000-0001-8320-1200

Joanna GiebułtowiczDepartment of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Medical University of Warsaw, 02-091 Warszawa, Poland.ORCID 0000-0002-2567-4453

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmaceuticals such as fluoxetine, paroxetine, sertraline, and mianserin occur in aquatic environments at low yet persistent concentrations due to their incomplete removal in wastewater treatment plants. Although frequently detected, these neuroactive compounds remain underrepresented in ecotoxicological assessments. Given their pharmacodynamic potency, environmentally relevant concentrations may induce sublethal effects in non-target organisms. In this study, we applied untargeted LC-MS-based metabolomics to investigate the sublethal effects of four widely used antidepressants-paroxetine, sertraline, fluoxetine (SSRIs), and mianserin (TeCA)-on two ecologically relevant freshwater invertebrates:

Indexed as

Antidepressive AgentsDaphniaMetabolic Networks and PathwaysMetabolomicsWater Pollutants, ChemicalAnimalsChromatography, LiquidDaphnia magnaFluoxetineLiquid Chromatography-Mass SpectrometryMass SpectrometryMetabolomeAntidepressive AgentsFluoxetineWater Pollutants, Chemicalenvironmental contaminationenvironmental toxicologymass spectrometrypharmaceuticalsuntargeted metabolomics

Identifiers

PMID40733218

DOI10.3390/molecules30142952

PMCPMC12300871

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.