Evidence map›Paper›PMID 40733206›Full record

ArticleMolecules (Basel, Switzerland)2025

Construction and Anti-Cancer Activity of a Self-Assembly Composite Nano-Delivery System Loaded with Curcumin.

Liang Chen, Qiao Wu, Chen Yang, Xiulan Xin, Zhaochu Xu, Shuai Luo, Hao Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liang ChenSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.ORCID 0000-0003-4895-6506
Qiao WuState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Chen YangSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.
Xiulan XinSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.
Zhaochu XuSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.
Shuai LuoSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.
Hao LiangState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.ORCID 0000-0002-4799-882X

Funding

The Project of Beijing Educational Science Planning grant No.CDDB22223
6 · The paper itself

Abstract

Natural products possess potent pharmacological activities and health benefits. However, drawbacks such as water insolubility, poor stability, and low bioavailability limit their practical applications. This research is dedicated to the development of suitable natural self-assembled nano-delivery systems to encapsulate natural molecule drugs, improving their dispersion and stability in aqueous solution. As a model drug, curcumin (Cur) was encapsulated in zinc-adenine nanoparticles (Zn-Adenine), based on the self-assembly of a coordination matrix material. Hyaluronic acid (HA) was further functionalized on the surface of Cur@(Zn-Adenine) to realize a tumor-targeted delivery system. The morphology was characterized through TEM and zeta potential analyses, while the encapsulation mechanism of the nanoparticles was researched via XRD and FTIR. The formed Cur@(Zn-Adenine)@HA nanoparticles exhibited good drug loading efficiency and drug loading rate. Moreover, compared to free Cur, Cur-loaded (Zn-Adenine)@HA showed enhanced pH stability and thermal stability. In particular, Cur@(Zn-Adenine)@HA demonstrated excellent biocompatibility and strong specificity for targeting CD44 protein on cancer cells. The above results indicate that (Zn-Adenine)@HA NPs can serve as an effective nano-delivery system for hydrophobic substances.

Indexed as

Antineoplastic AgentsCurcuminDrug Delivery SystemsNanoparticle Drug Delivery SystemNanoparticlesAdenineCell Line, TumorDrug CarriersDrug LiberationHumansHyaluronan ReceptorsHyaluronic AcidHydrogen-Ion ConcentrationZincAdenineAntineoplastic AgentsCurcuminDrug CarriersHyaluronan ReceptorsHyaluronic AcidNanoparticle Drug Delivery SystemZincadenineanti-cancercurcuminhyaluronic acidnatural self-assembled nano-delivery system

Identifiers

PMID40733206
PMCPMC12300573

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.