Synthesis and Application of a New Cyclic Phosphoric Acid in Enantioselective Three-Component Mannich Reactions.

Giovanni Ghigo, Alessio Robiolio Bose, Stefano Dughera

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Giovanni GhigoDepartment of Chemistry, University of Torino, Via Pietro Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-2480-5415

Alessio Robiolio BoseDepartment of Chemistry, University of Torino, Via Pietro Giuria 7, 10125 Torino, Italy.

Stefano DugheraDepartment of Chemistry, University of Torino, Via Pietro Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-6334-9897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel point-chiral six-membered cyclic phosphoric acid was synthesized starting from an enantiopure precursor via a concise three-step route. Its catalytic performance was evaluated in enantioselective three-component Mannich reactions. Under optimized conditions, the catalyst provided good yields and satisfactory enantiomeric excesses (up to 89%). The basic mechanism of the catalysis was also studied by the DFT method.

Indexed as

asymmetric catalysiscyclic phosphoric acidMannich reaction

Identifiers

PMID40733195

DOI10.3390/molecules30142928

PMCPMC12300773

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