Evidence map›Paper›PMID 40733191›Full record

ArticleMolecules (Basel, Switzerland)2025

Design, Synthesis, and Study of Protective Activity Against Stroke for Novel Water-Soluble Aldehyde Dehydrogenase 2 Activators.

Fengping Zhao, Zhenming Yu, Wei Tian, Xinhui Huang, Qingsen Zhang, Ruolan Zhou, Jian Hu, Shichong Yu, Xin Chen, Canhui Zheng

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fengping ZhaoSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Zhenming YuSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Wei TianGeneral Hospital of Central Theater Commond, Wuhan 430070, China.
Xinhui HuangThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Qingsen ZhangThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Ruolan ZhouSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Jian HuThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Shichong YuThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Xin ChenSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Canhui ZhengThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.

Funding

National Natural Science Foundation of China 82173670National Natural Science Foundation of China 82373735
6 · The paper itself

Abstract

Stroke poses a serious threat to human health, while there are very few drugs that can directly alleviate ischemia/reperfusion injury and improve the prognosis. Studies have shown that small-molecule activators of aldehyde dehydrogenase 2 (ALDH2) have the potential to become novel therapeutic drugs for ischemic stroke. In this study, through the systematic structural optimization of novel

Indexed as

Aldehyde Dehydrogenase, MitochondrialDrug DesignEnzyme ActivatorsNeuroprotective AgentsStrokeAnimalsDisease Models, AnimalHumansMaleMolecular Docking SimulationRatsRats, Sprague-DawleySolubilityStructure-Activity RelationshipWaterAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanAldh2 protein, ratEnzyme ActivatorsNeuroprotective AgentsWateractivatorsaldehyde dehydrogenase 2cerebral infarctionstrokewater-soluble

Identifiers

PMID40733191
PMCPMC12301025

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.