Evidence map›Paper›PMID 40733183›Full record

ArticleMolecules (Basel, Switzerland)2025

Pyrrolopyrimidines: Design, Synthesis and Antitumor Properties of Novel Tricyclic Pyrrolo [2,3-

Buer Song, Zarifa Murtazaeva, Lifei Nie, Rustamkhon Kuryazov, Shukhrat Gaybullaev, Chao Niu, Khurshed Bozorov, Haji Akber Aisa, Jiangyu Zhao

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Thieno[3,2-International journal of molecular sciences · 2026
    Review
  2. Review
  3. Scaffold-Hopping Design and Synthesis of Thieno[3,2-International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Buer SongState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Zarifa MurtazaevaDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.
Lifei NieState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Rustamkhon KuryazovDepartment of Chemistry, Urgench State University, Kh. Olimjon st. 14, Urgench 220100, Uzbekistan.
Shukhrat GaybullaevDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.ORCID 0009-0003-7753-4262
Chao NiuState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.ORCID 0000-0001-5943-6771
Khurshed BozorovState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.ORCID 0000-0001-7449-0936
Haji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.ORCID 0000-0003-4652-6879
Jiangyu ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.

Funding

CAM Resources Data Base" in the National Basic Science Data Center No. 443 NBSDC-DB-19Chinese Academy of Sciences President's International Fellowship 445 Initiative No. 2024VBA0021National Key R&D Program of China (No. 442 2020YFE0205600Organization of the laboratory for the creation of anticancer drugs No. ALM-444 202310062530
6 · The paper itself

Abstract

The pyrrolo[2,3-

Indexed as

Antineoplastic AgentsDrug DesignPyrimidinesPyrrolesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHT29 CellsHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsPyrimidinesPyrrolesPyrrolo(2,3-d)pyrimidinepyrrolopyrimidine7-deazapurineantitumor activitycarbonyl-amine condensationDDR2 receptorHT-29 cell linemolecular dockingN-halosuccinimidepyrrolo[2,3-d]pyrimidinepyrrolo[2,3-d]pyrimidine-iminesTf2O

Identifiers

PMID40733183
PMCPMC12299203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.