Evidence map›Paper›PMID 40733162›Full record

ArticleMolecules (Basel, Switzerland)2025

Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in

Nutchaninad Tanuphol, Corine Girard, Prapapan Temkitthawon, Nungruthai Suphrom, Nitra Nuengchamnong, Tongchai Saesong, Kamonlak Insumrong, Abdulaziz Wadeng, Wiyada Khangkhachit, Andy Zedet and 5 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nutchaninad TanupholCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0000-0003-3350-9017
Corine GirardUniversité Marie et Louis Pasteur, EFS, INSERM RIGHT (UMR1098), F-25000 Besançon, France.ORCID 0000-0002-5116-1395
Prapapan TemkitthawonCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Nungruthai SuphromDepartment of Chemistry, Faculty of Sciences, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0000-0003-3767-8387
Nitra NuengchamnongScience Laboratory Center, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.
Tongchai SaesongCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Kamonlak InsumrongDepartment of Chemistry, Faculty of Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Abdulaziz WadengDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Wiyada KhangkhachitCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Andy ZedetUniversité Marie et Louis Pasteur, EFS, INSERM RIGHT (UMR1098), F-25000 Besançon, France.ORCID 0000-0002-8794-4375
Ratchadaree IntayotCenter of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.
Siriporn JungsuttiwongCenter of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.ORCID 0000-0001-5943-6878
Anuchit PlubrukarnDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.ORCID 0000-0002-2340-7220
Francois SenejouxUniversité Marie et Louis Pasteur, EFS, INSERM RIGHT (UMR1098), F-25000 Besançon, France.ORCID 0000-0002-3643-2804
Kornkanok IngkaninanCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0000-0002-4415-8489

Funding

Agricultural Research Development Agency 2564/1Franco-Thai Scholarship ProgramGlobal and Frontier Research University Fund, Naresuan University R2566C053Ministry of Higher Education, Science, Research and Innovation (MHESI) via Reinventing University Program 2023Naresuan University and the Center of Excellence for Innovation in Chemistry ((PERCH-CIC)National Research Council of ThailandNational Science, Research and 504 Innovation Fund (NSRF) via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation B16F640099
6 · The paper itself

Abstract

The inhibition of steroid 5-alpha reductase (S5AR), a key mechanism for managing dihydrotestosterone-dependent conditions, has been demonstrated in teak (

Indexed as

5-alpha Reductase InhibitorsMetabolomicsPlant ExtractsPlant LeavesDrug DiscoveryHumans5-alpha Reductase InhibitorsPlant Extractsmetabolomicssteroid 5-alpha reductase inhibitorstructure elucidationTectona grandis L.f.

Identifiers

PMID40733162
PMCPMC12300835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.