Evidence map›Paper›PMID 40733123›Full record

ArticlePharmaceutics2025

Pharmacokinetics of Pegaspargase with a Limited Sampling Strategy for Asparaginase Activity Monitoring in Children with Acute Lymphoblastic Leukemia.

Cristina Matteo, Antonella Colombini, Marta Cancelliere, Tommaso Ceruti, Ilaria Fuso Nerini, Luca Porcu, Massimo Zucchetti, Daniela Silvestri, Maria Grazia Valsecchi, Rosanna Parasole and 12 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Cristina MatteoLaboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.ORCID 0000-0001-8910-1104
Antonella ColombiniDepartment of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Marta CancelliereLaboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.ORCID 0009-0000-9963-4457
Tommaso CerutiLaboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Ilaria Fuso NeriniLaboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Luca PorcuLaboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Massimo ZucchettiLaboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.ORCID 0000-0002-5427-052X
Daniela SilvestriTettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Maria Grazia ValsecchiBiostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0001-5574-3504
Rosanna ParasoleDipartimento di Oncologia, Ematologia e Terapie Cellulari, AORN Santobono-Pausilipon, 80122 Napoli, Italy.ORCID 0000-0003-3350-5286
Luciana VintiDipartimento di Onco-Ematologia e Terapia Cellulare e Genica, Ospedale Pediatrico Bambino Gesù, 00050 Rome, Italy.ORCID 0000-0003-2803-992X
Nicoletta BertorelloOncoematologia Pediatrica, Ospedale Infantile Regina Margherita, Città della Salute e della Scienza, 10126 Torino, Italy.
Daniela OnofrilloOncoematologia Pediatrica, Dipartimento di Oncologia e Ematologia, Ospedale Civile Spirito Santo, 65100 Pescara, Italy.
Massimo ProvenziOncologia Pediatrica, Ospedale Papa Giovanni XXIII, 24127 Bergamo, Italy.
Elena ChioccaDepartment of Hematology-Oncology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.
Luca Lo NigroCentro di Ematologia ed Oncologia Pediatrica, Azienda Ospedaliero Universitaria, Policlinico "G. Rodolico-San Marco", 95100 Catania, Italy.ORCID 0000-0002-2480-1799
Laura Rachele BettiniDepartment of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Giacomo GottiDepartment of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Silvia BungaroDepartment of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Martin SchrappeDepartment of Paediatrics, Christian-Albrechts-University Kiel and University Medical Centre Schleswig-Holstein, 24118 Kiel, Germany.
Paolo UbezioLaboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.ORCID 0000-0003-0412-9891
Carmelo RizzariDepartment of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute lymphoblastic leukemia (ALL)asparaginase (ASPase)L-asparagine (Asn)limited sampling strategypegylated asparaginase (PEG-ASPase)pharmacokinetics (PK)serum ASPase activity (SAA)

Identifiers

PMID40733123
PMCPMC12297903

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.