Evidence map›Paper›PMID 40732731›Full record

Observational studyPathogens (Basel, Switzerland)2025

Restoring Control: Real-World Success with Imipenem-Relebactam in Critical MDR Infections-A Multicenter Observational Study.

Andrea Marino, Giuseppe Pipitone, Emmanuele Venanzi Rullo, Federica Cosentino, Rita Ippolito, Roberta Costa, Sara Bagarello, Ylenia Russotto, Chiara Iaria, Bruno Cacopardo and 1 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Addressing therapeutic options for KPC-3-producing ST307-Antimicrobial agents and chemotherapy · 2026
    Article
  3. Review
  4. Article
  5. Effectiveness of imipenem-relebactam for multidrug-resistantAntimicrobial agents and chemotherapy · 2025
    Observational
  6. Advances inMicroorganisms · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrea MarinoDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, 95122 Catania, Italy.ORCID 0000-0002-5650-6911
Giuseppe PipitoneInfectious Diseases Unit, ARNAS Civico-Di Cristina, 90127 Palermo, Italy.ORCID 0000-0002-3408-4877
Emmanuele Venanzi RulloUnit of Infectious Diseases, G. Martino University Hospital, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.ORCID 0000-0001-8273-5382
Federica CosentinoDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, 95122 Catania, Italy.
Rita IppolitoUnit of Infectious Diseases, G. Martino University Hospital, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
Roberta CostaDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, 95122 Catania, Italy.
Sara BagarelloInfectious Diseases Unit, ARNAS Civico-Di Cristina, 90127 Palermo, Italy.
Ylenia RussottoUnit of Infectious Diseases, G. Martino University Hospital, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.ORCID 0000-0001-9514-133X
Chiara IariaInfectious Diseases Unit, ARNAS Civico-Di Cristina, 90127 Palermo, Italy.
Bruno CacopardoDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, 95122 Catania, Italy.
Giuseppe NunnariDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, 95122 Catania, Italy.ORCID 0000-0002-8113-8452

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase InhibitorsDrug Resistance, Multiple, BacterialGram-Negative Bacterial InfectionsImipenemAgedCritical IllnessFemaleHumansItalyMaleMiddle AgedProspective StudiesRetrospective StudiesTreatment OutcomeAnti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase InhibitorsImipenemrelebactamantimicrobial stewardshipEnterobacteralesimipenem-relebactamKlebsiella pneumoniaeMDR bacteriaPseudomonas aeruginosa

Identifiers

PMID40732731
PMCPMC12298671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.