Evidence map›Paper›PMID 40732713›Full record

ArticlePathogens (Basel, Switzerland)2025

Pharmacokinetics of Molnupiravir in Cats with Naturally Occurring Feline Infectious Peritonitis.

Petra Černá, Luke Wittenburg, Jennifer Hawley, McKenna Willis, Britta Siegenthaler, Michael R Lappin

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Petra ČernáDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-4300-8534
Luke WittenburgDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA.
Jennifer HawleyDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
McKenna WillisDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Britta SiegenthalerDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Michael R LappinDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

Funding

EveryCat Health Foundation EC24F-297
6 · The paper itself

Abstract

Antiviral drugs like EIDD-2801 (molnupiravir; MPV) have been successfully used in the treatment of feline infectious peritonitis (FIP). The previous study of the pharmacokinetics of MPV in healthy cats showed promise for its use and safety. The objective was to determine the pharmacokinetics of molnupiravir in cats with naturally occurring FIP by measuring MPV and EIDD-193 (β-D-N4-hydroxycytidine; NHC) serum levels. Blood was collected from seven cats diagnosed with naturally occurring FIP treated at 1, 2, 4, 6 and 12 h post oral MPV administration and at 12 h post pill administration 7 days later. Serum concentrations of MPV and NHC were determined using a previously published high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. The mean dose of MPV was 15.44 mg/kg (SD ± 1.82). The mean peak serum concentration of MPV (C

Indexed as

Antiviral AgentsCytidineFeline Infectious PeritonitisHydroxylaminesAnimalsCatsChromatography, High Pressure LiquidFemaleHalf-LifeMaleTandem Mass SpectrometryAntiviral AgentsCytidineHydroxylaminesmolnupiravirantiviral therapycoronavirusMPV

Identifiers

PMID40732713
PMCPMC12299796

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.