Evidence map›Paper›PMID 40732693›Full record

ReviewPathogens (Basel, Switzerland)2025

Mass Spectrometry Imaging: Revolutionizing Molecular Insights in Infectious Diseases Research.

Minmin Zhang, Xiao Wang, Xiaoling Su, Aidiya Yimamu, Lanjuan Li, Zeyu Sun

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minmin ZhangJinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, China.
Xiao WangJinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, China.
Xiaoling SuState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Aidiya YimamuState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.ORCID 0009-0000-1692-3596
Lanjuan LiJinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, China.
Zeyu SunJinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, China.

Funding

National Natural Science Foundation of China 82370612Research Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2025002B, JNL-2025001AShandong Provincial Laboratory Project SYS202202The Fundamental Research Funds for the Central Universities 2025ZFJH03Zhejiang Provincial Natural Science Foundation of China TGC24C050004
6 · The paper itself

Abstract

Infectious diseases remain a leading cause of mortality worldwide. The pathogenesis that comprises infection, focal inflammation, and immuno-response, typically occurs in one or multiple organs or tissues. Analysis of the molecular composition of affected tissues with their spatial context is pivotal to elucidate the underlying disease mechanisms and to develop accurate diagnostic strategies. In recent years, mass spectrometry imaging (MSI) technology has achieved significant advancements and has emerged as an powerful tool for tissue-based molecular exploration with high molecular specificity and spatial resolution. Although MSI has been rapidly adopted in numerous branches of biomedical research, its application in the field of infectious diseases research is still in its early stages. With this in mind, this review aims to familiarize infectious disease researchers with the advantages and diverse applications of MSI. Additionally, we delineate several existing technical challenges, application pitfalls, and the potential solutions to overcome these challenges.

Indexed as

Communicable DiseasesMass SpectrometryMolecular ImagingAnimalsBiomedical ResearchHumansbiomarkersinfectious diseasesmass spectrometry imagingmicroorganismpharmacology

Identifiers

PMID40732693
PMCPMC12298636

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.