Evidence map›Paper›PMID 40732663›Full record

ArticlePathogens (Basel, Switzerland)2025

Immune-Pathological Correlates of Disease Severity in New-World Kala-Azar: The Role of Parasite Load and Cytokine Profiles.

Ingridi de Souza Sene, Dorcas Lamounier Costa, Daniele Alves Zacarias, Jailthon Carlos Dos Santos, Gabriel Reis Ferreira, Daniela Rodrigues Andrade, Jorge Clarêncio de Sousa Andrade, Carlos Henrique Nery Costa

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Temperature Effect on Parasitism in Auricularia Larva of the Sea CucumberAnimals : an open access journal from MDPI · 2026
    Article
  3. Article
  4. Article
  5. Interleukin-8 Predicts Fatal Kala-Azar: A Case-Control Study.Tropical medicine and infectious disease · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ingridi de Souza SeneLaboratory of Leishmaniasis, Institute of Tropical Medicine Natan Portella, Teresina 64002-510, Brazil.
Dorcas Lamounier CostaLaboratory of Leishmaniasis, Institute of Tropical Medicine Natan Portella, Teresina 64002-510, Brazil.ORCID 0000-0001-7115-7978
Daniele Alves ZacariasLaboratory of Leishmaniasis, Institute of Tropical Medicine Natan Portella, Teresina 64002-510, Brazil.
Jailthon Carlos Dos SantosLaboratory of Leishmaniasis, Institute of Tropical Medicine Natan Portella, Teresina 64002-510, Brazil.
Gabriel Reis FerreiraIntelligence Center for Emerging and Tropical Diseases (CIATEN), Teresina 64049-550, Brazil.
Daniela Rodrigues AndradeIntegrated Laboratory of Microbiology and Immunoregulation, CPqGM-Fiocruz-Bahia, Salvador 40296-710, Brazil.
Jorge Clarêncio de Sousa AndradeIntegrated Laboratory of Microbiology and Immunoregulation, CPqGM-Fiocruz-Bahia, Salvador 40296-710, Brazil.
Carlos Henrique Nery CostaLaboratory of Leishmaniasis, Institute of Tropical Medicine Natan Portella, Teresina 64002-510, Brazil.ORCID 0000-0001-7302-2006

Funding

National Council for Scientific and Technological Development 475102/2011-8
6 · The paper itself

Abstract

Kala-azar is a protracted disease caused by the protozoan

Indexed as

CytokinesLeishmania infantumLeishmaniasis, VisceralParasite LoadAdultAgedBone MarrowDNA, ProtozoanFemaleHumansMaleMiddle AgedSeverity of Illness IndexYoung AdultCytokinesDNA, Protozoanadaptative immunitybone marrowhemorrhageHIV-coinfectionIL-12innate immune responseLeishmania infantummortalitysepsisvisceral leishmaniasis

Identifiers

PMID40732663
PMCPMC12299585

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.