Evidence map›Paper›PMID 40732453›Full record

ArticleSensors (Basel, Switzerland)2025

Ultrasmall Superparamagnetic Magnetite Nanoparticles as Glutamate-Responsive Magnetic Resonance Sensors.

Hannah Mettee, Aaron Asparin, Zulaikha Ali, Shi He, Xianzhi Li, Joshua Hall, Alexis Kim, Shuo Wu, Morgan J Hawker, Masaki Uchida and 1 more

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hannah MetteeDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.
Aaron AsparinDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.
Zulaikha AliDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.
Shi HeDepartment of Electrical and Computer Engineering, California State University Fresno, 2320 E San Ramon Ave, Fresno, CA 93740, USA.ORCID 0000-0002-5713-8233
Xianzhi LiDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.
Joshua HallDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.ORCID 0009-0000-6297-9427
Alexis KimDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.
Shuo WuDepartment of Electrical and Computer Engineering, California State University Fresno, 2320 E San Ramon Ave, Fresno, CA 93740, USA.ORCID 0000-0001-6146-3613
Morgan J HawkerDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.ORCID 0000-0002-1607-9564
Masaki UchidaDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.
He WeiDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E San Ramon Ave, Fresno, CA 93740, USA.ORCID 0000-0001-7188-8105

Funding

California State University, Fresno Start-up fundsCSUBIOTECH Program Doris A. Howell Foundation - Research Scholar Award
6 · The paper itself

Abstract

Glutamate, the primary excitatory neurotransmitter in the central nervous system, plays a pivotal role in synaptic signaling, learning, and memory. Abnormal glutamate levels are implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and ischemic stroke. Despite the utility of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in diagnosing such conditions, the development of effective glutamate-sensitive contrast agents remains a challenge. In this study, we present ultrasmall, citric acid-coated superparamagnetic iron oxide nanoparticles (CA-SPIONs) as highly selective and sensitive MRS probes for glutamate detection. These 5 nm magnetite CA-SPIONs exhibit a stable dispersion in physiological buffers and undergo aggregation in the presence of glutamate, significantly enhancing the T

Indexed as

Biosensing TechniquesGlutamic AcidMagnetic Resonance ImagingMagnetite NanoparticlesCitric AcidContrast MediaHumansMagnetic Resonance SpectroscopyCitric AcidContrast MediaGlutamic AcidMagnetite Nanoparticleseco-friendlyglutamate biosensorsmagnetic resonance spectroscopysuperparamagnetic iron oxide nanoparticles

Identifiers

PMID40732453
PMCPMC12298936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.