Evidence map›Paper›PMID 40732296›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

A Machine Learning Platform for Isoform-Specific Identification and Profiling of Human Carbonic Anhydrase Inhibitors.

Lisa Piazza, Miriana Di Stefano, Clarissa Poles, Giulia Bononi, Giulio Poli, Gioele Renzi, Salvatore Galati, Antonio Giordano, Marco Macchia, Fabrizio Carta and 2 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lisa PiazzaDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0009-0007-5062-4590
Miriana Di StefanoDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-6727-5816
Clarissa PolesTelethon Institute of Genetics and Medicine, 80078 Naples, Italy.ORCID 0009-0008-6947-7903
Giulia BononiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4336-4344
Giulio PoliDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Gioele RenziDepartment of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, Sesto Fiorentino, 50019 Firenze, Italy.ORCID 0009-0008-9109-030X
Salvatore GalatiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-1959-5839
Antonio GiordanoSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-5959-016X
Marco MacchiaDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Fabrizio CartaDepartment of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, Sesto Fiorentino, 50019 Firenze, Italy.ORCID 0000-0002-1141-6146
Claudiu T SupuranDepartment of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, Sesto Fiorentino, 50019 Firenze, Italy.ORCID 0000-0003-4262-0323
Tiziano TuccinardiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-6205-4069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

carbonic anhydrasedrug discoveryisoform selectivitymachine learningSHAPvirtual screening

Identifiers

PMID40732296
PMCPMC12300992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.