Evidence map›Paper›PMID 40732285›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Pharmacogenetic Biomarkers of Ibrutinib Response and Toxicity in Chronic Lymphocytic Leukemia: Insights from an Observational Study.

Noelia Pérez-Gómez, Antonio Sanz-Solas, Beatriz Cuevas, María Victoria Cuevas, Cristina Alonso-Madrigal, Javier Loscertales, Rodolfo Álvarez-Nuño, Covadonga García, Pablo Zubiaur, Gonzalo Villapalos-García and 12 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Noelia Pérez-GómezResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.ORCID 0009-0007-4694-7469
Antonio Sanz-SolasResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.
Beatriz CuevasHematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.
María Victoria CuevasHematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.
Cristina Alonso-MadrigalHematology Department, Hospital Santiago Apóstol, Miranda de Ebro, 09200 Burgos, Spain.
Javier LoscertalesHematology Department, Hospital Universitario de La Princesa, 28006 Madrid, Spain.ORCID 0000-0003-3561-3758
Rodolfo Álvarez-NuñoHematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.
Covadonga GarcíaHematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.
Pablo ZubiaurGrupo 32, Instituto de Investigación Sanitaria La Princesa (IP), Hospital Universitario de La Princesa, 28006 Madrid, Spain.ORCID 0000-0002-6150-4320
Gonzalo Villapalos-GarcíaClinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria La Princesa (IP), 28006 Madrid, Spain.ORCID 0000-0002-4849-3268
Raúl Miguel Parra-GarcésClinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria La Princesa (IP), 28006 Madrid, Spain.ORCID 0000-0002-3061-8659
Gina Mejía-AbrilClinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria La Princesa (IP), 28006 Madrid, Spain.ORCID 0000-0002-8689-7941
Raquel AlcarazResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.
Raquel VinuesaResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.
Francisco Javier Díaz-GálvezHematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.
María González-OterResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.ORCID 0009-0000-1887-4644
Natalia García-SanchaResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.ORCID 0000-0001-7731-7020
Raúl Azibeiro-MelchorHematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.ORCID 0000-0002-3382-3674
Tomás José González-LópezHematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.ORCID 0000-0003-2458-2554
Francisco Abad-SantosPharmacology Department, Facultad de Medicina, Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0002-6519-8885
Jorge LabradorResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.ORCID 0000-0002-3696-0287
Miriam Saiz-RodríguezResearch Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain.

Funding

Fundación hna 2nd edition of the Scientific Health Research AwardInstituto de Salud Carlos III (ISCIII), Spanish Ministry of Science and Innovation CD21/00022ISCIII and the European Social Fund FI20/00090Regional Health Management of Castilla y León GRS 2202/A/2020
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chronic lymphocytic leukemiaibrutinibpharmacogeneticspolymorphisms

Identifiers

PMID40732285
PMCPMC12299598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.