Evidence map›Paper›PMID 40732280›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs.

Ren-Jong Liang, Shu-Hao Hsu, Hsueh-Tien Chen, Wan-Han Chen, Han-Yu Fu, Hsin-Ying Chen, Hong-Jaan Wang, Sung-Ling Tang

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ren-Jong LiangClinical Pharmacy Department, Tri-Service General Hospital Keelung Branch, Keelung City 202006, Taiwan.
Shu-Hao HsuSchool of Pharmacy, National Defense Medical Center, Taipei 114201, Taiwan.ORCID 0000-0002-6658-6441
Hsueh-Tien ChenSchool of Pharmacy, National Defense Medical Center, Taipei 114201, Taiwan.ORCID 0009-0003-7977-6871
Wan-Han ChenSchool of Pharmacy, National Defense Medical Center, Taipei 114201, Taiwan.
Han-Yu FuSchool of Pharmacy, National Defense Medical Center, Taipei 114201, Taiwan.
Hsin-Ying ChenGraduate Institute of Life Science, National Defense Medical Center, Taipei 114201, Taiwan.
Hong-Jaan WangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114201, Taiwan.ORCID 0000-0002-8206-896X
Sung-Ling TangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114201, Taiwan.ORCID 0000-0002-4335-2992

Funding

Ministry of National Defense, Taiwan MND-MAB-D-113119National Science and Technology Council, Taipei, Taiwan NSCT 113-2320-B-016-003-MY2Tri-Service General Hospital Keelung Branch, Keelung, Taiwan TSGH-KL_E_114007
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

hepatic clearancein vitro-to-in vivo extrapolation (IVIVE)isolated perfused rat liver (IPRL)modified well-stirred model (MWSM)protein bindingwell-stirred model (WSM)

Identifiers

PMID40732280
PMCPMC12299470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.