Evidence map›Paper›PMID 40732039›Full record

ArticleMicroorganisms2025

Genetic Correlates of Synergy Mechanisms of Daptomycin Plus Fosfomycin in Daptomycin-Susceptible and -Resistant Methicillin-Resistant

Warren E Rose, Selvi C Ersoy, Wessam Abdelhady, Alan R Dominguez, Jedidiah Ndam Muyah Manna, Jorge N Artaza, Reetakshi Mishra, Ahmed M Elsayed, Richard A Proctor, Sarah L Baines and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Warren E RoseSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0001-5012-5993
Selvi C ErsoyDivision of Infectious Diseases, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.ORCID 0000-0002-8792-2061
Wessam AbdelhadyDivision of Infectious Diseases, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Alan R DominguezDepartment of Health and Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
Jedidiah Ndam Muyah MannaDepartment of Health and Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
Jorge N ArtazaDepartment of Health and Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
Reetakshi MishraCypress High School, Cypress, CA 90630, USA.
Ahmed M ElsayedDivision of Infectious Diseases, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Richard A ProctorDepartments of Medicine and Medical Microbiology & Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Sarah L BainesDepartment of Microbiology & Immunology, The University of Melbourne at the Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Benjamin P HowdenDepartment of Microbiology & Immunology, The University of Melbourne at the Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Nagendra N MishraDivision of Infectious Diseases, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

Funding

The Lundquist Institute at Harbor-UCLA intramural research grant to NNM; NIH/NIAID to WER. 533122-01-00 & 862412-00-00; R01-AI132627
6 · The paper itself

Abstract

This study elucidates potential genetic determinants and mechanisms involved in the synergistic effects of daptomycin (DAP) + fosfomycin (FOF) combination therapy. Among 33 clinically derived DAP-susceptible (S)/DAP-resistant (R) isogenic strain pairs, mutations in the

Indexed as

combination therapydaptomycinfosfomycinMRSAtranscriptomics

Identifiers

PMID40732039
PMCPMC12299106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.