Evidence map›Paper›PMID 40731840›Full record

ReviewMedicina (Kaunas, Lithuania)2025

Biomarkers and Neuropsychological Tools in Attention-Deficit/Hyperactivity Disorder: From Subjectivity to Precision Diagnosis.

Ion Andrei Hurjui, Ruxandra Maria Hurjui, Loredana Liliana Hurjui, Ionela Lacramioara Serban, Irina Dobrin, Mihai Apostu, Romeo Petru Dobrin

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ion Andrei HurjuiDepartment of Medicine III, Discipline of Psychiatry, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Ruxandra Maria HurjuiDepartment of Morpho-Functional Sciences I, Discipline of Histology, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Loredana Liliana HurjuiDepartment of Morpho-Functional Sciences II, Physiology Discipline, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0003-3803-9405
Ionela Lacramioara SerbanDepartment of Morpho-Functional Sciences II, Physiology Discipline, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Irina DobrinDepartment of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universității Street, 700115 Iasi, Romania.
Mihai ApostuDepartment of Analytical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universității Street, 700115 Iasi, Romania.
Romeo Petru DobrinDepartment of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universității Street, 700115 Iasi, Romania.ORCID 0000-0003-3023-0205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with chronic inattention, hyperactivity, and impulsivity and is linked with significant functional impairment. Despite being highly prevalent, diagnosis of ADHD continues to rely on subjective assessment reports of behavior and is often delayed or inaccurate. This review summarizes current advances in biomarkers and neuropsychological tests for the improvement of ADHD diagnosis and treatment. Key biomarkers are neuroimaging methods (e.g., structural and functional MRI), electrophysiological measures (e.g., EEG, ERP), and biochemical measures (e.g., cortisol, vitamin D). Additionally, novel experimental measures, e.g., eye-tracking, pupillometry, and microbiome analysis, hold the promise to be objective and dynamic measures of ADHD symptoms. The review also comments on the impact of the burden of ADHD on quality of life, e.g., emotional well-being, academic achievement, and social functioning. Additionally, differences between individuals, such as age, sex, comorbidities, and the impact of social and family support, are also addressed in relation to ADHD outcomes. In summary, we highlight the potential of these emerging biomarkers and tools to revolutionize ADHD diagnosis and guide personalized treatment strategies. These insights have significant implications for improving patient outcomes.

Indexed as

Attention Deficit Disorder with HyperactivityBiomarkersNeuropsychological TestsHumansNeuroimagingPrecision MedicineBiomarkersattentionattention-deficit hyperactivity disorderbiomarkerscognitive dysfunctioncortisolelectroencephalographyeye-trackingmicrobiomeneuroimagingquality of life

Identifiers

PMID40731840
PMCPMC12300379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.