Evidence map›Paper›PMID 40731694›Full record

ArticleMicromachines2025

Automated Antithrombin Activity Detection with Whole Capillary Blood Based on Digital Microfluidic Platform.

Dongshuo Li, Hanqi Hu, Hanzhi Zhang, Lei Shang, Tao Zhao, Qingchen Zhao, Shuhao Zhang, Fucun Ma, Guowei Liang, Rongxin Fu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongshuo LiDepartment of Clinical Laboratory, Aerospace Center Hospital, Beijing 100049, China.
Hanqi HuSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Hanzhi ZhangSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Lei ShangDepartment of Clinical Laboratory, Aerospace Center Hospital, Beijing 100049, China.
Tao ZhaoSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Qingchen ZhaoSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Shuhao ZhangSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Fucun MaDepartment of Clinical Laboratory, Aerospace Center Hospital, Beijing 100049, China.
Guowei LiangDepartment of Clinical Laboratory, Aerospace Center Hospital, Beijing 100049, China.ORCID 0000-0002-9772-7286
Rongxin FuSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Xuekai LiuDepartment of Clinical Laboratory, Aerospace Center Hospital, Beijing 100049, China.

Funding

the Aerospace Center Hospital Research Fund YN202514the National Key R&D Program of China Grants 2023YFF0721500the National Natural Science Foundation of China Grants 62105177the Natural Science Foundation of Chongqing Grant 2024NSCQMSX3784the State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen University, Grant OEMT-2024-KF-03the Young Elite Scientists Sponsorship Program of CAST Grant 2023QNRC001
6 · The paper itself

Abstract

Antithrombin (AT) plays a crucial role in the human anticoagulant system and has extensive clinical applications. However, traditional detection methods often require large sample volumes, complex procedures, and lengthy processing times.

methodsWe integrated digital microfluidics technology with AT detection to develop a point-of-care testing (POCT) device that is user-friendly and fully automated for real-time AT testing.

resultsThis device allows for automation and enhanced adaptability to various settings, requiring only a minimal sample volume (whole capillary blood), thereby omitting steps such as plasma separation to save time and improve clinical testing efficiency. Comparisons with conventional AT activity detection methods demonstrate a high degree of consistency in the results obtained with this device.

conclusionThe AT detection system we developed exhibits significant effectiveness and holds substantial research potential, positioning it to evolve into a clinically impactful POCT solution for AT assessment.

Indexed as

ATin vitro diagnosticsmicrofluidicsoptical biosensorspoint-of-care testing

Identifiers

PMID40731694
PMCPMC12298285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.