ArticleBMC ophthalmology2025
Critical factors to predict efficacy of orthokeratology in inhibiting axial elongation in myopic children.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Diffractive optical element (D.O.E) spectacle lenses for myopia prevention and control: a small-scale pilot study among younger Chinese children.BMJ open ophthalmology · 2026Trial
- Compliance with orthokeratology lens wear: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Real-World Comparison of the Effectiveness of Defocus Incorporated Multiple Segments and Myopi-X Spectacle Lenses for Myopia Control in Turkish Children: A Retrospective Study.Turkish journal of ophthalmology · 2026Observational
- The effect of defocus incorporated multiple segments (DIMS) spectacle lenses on astigmatism in children with myopia.Scientific reports · 2026Article
- The role of astigmatism in myopia development, myopia progression and myopia control.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe efficacy of orthokeratology (Ortho-K) in controlling myopia is influenced by many complex factors, which makes predicting the effect of myopia control a complicated task. This study aimed to analyze the relevant factors that can predict the axial length elongation (ALE) in patients wearing Ortho-K, including baseline ocular parameters, genetic factors and lifestyle habits.
methodsIn this retrospective study, 542 eyes from 300 myopic children wearing Ortho-K were reviewed from the Optometry Centre of Peking University People's Hospital from January 2022 to December 2023. Baseline characteristics such as age, gender, spherical equivalent refraction (SER), horizontal visible iris diameter (HVID), mean keratometry value (mean K), corneal astigmatism, corneal eccentricity (E-value), anterior chamber depth (ACD), central corneal thickness (CCT), pupil diameter (PD), treatment zone area (TZA) and treatment zone decentration distance were measured. Additionally, parental factors and lifestyle habits, including parental myopia status, continuous near-work time, weight change, height change, age of diagnosis of myopia, eating sweets, regular follow-ups, online-class, interest class, outdoor activity and reading and writing posture were collected via questionnaires. Linear mixed effect model was constructed to identify factors associated with ALE.
resultsLinear mixed effect model revealed that patients had a higher ALE who started wearing Ortho-k lenses at a younger age (P < 0.001), had less myopia (P < 0.001), high-myopia in both parents (P = 0.018). Conversely, patients had slower ALE with a larger decentration distance of the treatment zone (P = 0.002) and regular follow-ups (P = 0.001).
conclusionsAge, SER and parental high myopia are critical factors to predict efficacy of orthokeratology in inhibiting axial elongation in myopic children. Orthokeratology lens decentration and regular follow-ups have a positive impact on myopia control. The decentration can be considered preserved when there is no obvious visual interference or complications.
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