ArticleBMC gastroenterology2025
Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Development and Validation of an Interpretable Machine Learning Model to Predict Mortality in Patients With Sepsis-Induced Coagulopathy: Multicenter Cohort Study.JMIR medical informatics · 2026Article
- Prediction of hospital length of stay in decompensated cirrhosis using hematologic and inflammatory indices.American journal of translational research · 2026Article
- Sex differences in the association between red cell distribution width and 30-day mortality in critically ill patients with acute cholangitis: a retrospective cohort study.BMC gastroenterology · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between red blood cell distribution width (RDW) and short- and long-term all-cause mortality in patients with acute pancreatitis (AP) and sepsis remains unclear.
methodsData were extracted from the MIMIC-IV database for patients diagnosed with AP and sepsis. The primary research endpoints were all-cause mortality at 28, 90, and 365 days. Kaplan-Meier survival curve analysis, restricted cubic spline (RCS) receiver operating characteristic (ROC) curves, subgroup analysis, and Cox regression were employed to assess the association between RDW and mortality.
resultsA total of 759 patients with AP and sepsis were included. The all-cause mortality rates were 17.26%, 25.96%, and 31.49% at 28, 90, and 365 days, respectively. Cox regression analysis indicated that, after adjustment for covariates, elevated RDW was significantly associated with increased risk of mortality at 28, 90, and 365 days. The hazard ratios (HR) were 1.08 (95% CI: 1.02-1.14) for 28-day mortality, 1.12 (95% CI: 1.07-1.17) for 90-day mortality, and 1.13 (95% CI: 1.08-1.18) for 365-day mortality. The RCS analysis indicated a nonlinear relationship. Kaplan-Meier analysis demonstrated significantly higher mortality in the high-RDW group compared to the low-RDW group (p < 0.001). The area under the curve (AUC) for RDW was greater than that for BISAP and SIRS, but lower than the SOFA. Subgroup analyses showed no significant interactions between RDW and most subgroups.
conclusionElevated RDW is independently associated with increased short- and long-term all-cause mortality in patients with AP and sepsis.
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