Evidence map›Paper›PMID 40731307›Full record

ArticleRenal failure2025

DNA-PKcs participates in the repair of renal tubular epithelial cell injury.

Dan Feng, Yu-Jie Hu, Lei Sun, Jing Zhang, Xiao-Ling Niu, Wen-Yan Huang

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Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dan FengDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Yu-Jie HuDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Lei SunDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Jing ZhangDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiao-Ling NiuDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Wen-Yan HuangDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) and plays a central role in mediating cell damage and ultimately acute tubular necrosis. Renal proximal tubular epithelial cells (PTECs) possess intrinsic repair mechanisms, yet the molecular pathways underpinning their ability to recover after I/R injury remain incompletely understood. DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine/threonine kinase, is pivotal in DNA damage repair, genomic stability, cell cycle regulation, and mitochondrial dysfunction. Given its central roles in maintaining cellular homeostasis, we hypothesized that DNA-PKcs is critically involved in orchestrating the intrinsic repair mechanisms of renal tubular epithelial cells following I/R injury. In this study, we investigate the involvement of DNA-PKcs in the repair of tubular epithelial cell damage induced by renal I/R injury. Using both

Indexed as

Acute Kidney InjuryDNA-Activated Protein KinaseEpithelial CellsKidney Tubules, ProximalReperfusion InjuryAnimalsCell LineChromonesDisease Models, AnimalDNA-Binding ProteinsDNA DamageHumansKidney TubulesMaleMiceMorpholinesChromonesDNA-Activated Protein KinaseDNA-Binding ProteinsMorpholinesPrkdc protein, mouseDNA-PKcsDNA-PKcs inhibitorrenal tubular epithelial cell injuryrepair

Identifiers

PMID40731307
PMCPMC12308869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.