ReviewEndocrinology, diabetes & metabolism2025
Disparities in Peripheral Circulatory Complication-Related Mortality in Type 2 Diabetes Mellitus Patients: A CDC Analysis (1999-2020).
Review in Endocrinology, diabetes & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Methodological Shortcomings in a Study of Peripheral Circulatory Complications in Type 2 Diabetes.Endocrinology, diabetes & metabolism · 2026Article
- Disparities in Peripheral Circulatory Complication-Related Mortality in Type 2 Diabetes Mellitus Patients: A CDC Analysis (1999-2020).Endocrinology, diabetes & metabolism · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPeripheral circulatory complication (PCC), a significant complication of type 2 diabetes mellitus (T2DM), poses a considerable mortality burden in the United States. This study aimed to analyse demographic and geographic disparities in PCC-related mortality in T2DM patients from 1999 to 2020.
methodsUtilising the CDC WONDER database, we utilised death certificates to identify PCC-related deaths using ICD-10 Code E11.5 and calculated age-adjusted mortality rates (AAMRs) per 1,000,000 individuals. Joinpoint regression analysis was used to assess annual percent changes (APCs) in mortality rates.
resultsPCC caused 81,793 deaths. The AAMR increased from 1999 to 2004 (APC: 5.88, 95% CI: 2.44 to 12.70), followed by a decrease from 2004 to 2014 (APC: -3.70, 95% CI: -5.83 to -2.45), and an increase again until 2020 (APC: 8.34, 95% CI: 6.05 to 11.50). Males consistently exhibited higher mortality rates (AAMR: 11.08, 95% CI: 11.00 to 11.6) than females (AAMR: 8.34, 95% CI: 8.26 to 8.43). Racial/ethnic disparities were evident, with American Indian or Alaskan natives showing the highest AAMR (19.76) compared to Asian or Pacific Islanders (6.11). Geographic disparities were observed, with the Midwest region (AAMR: 12.86) and West Virginia (AAMR: 18.52) exhibiting significantly higher mortality rates.
conclusionMortality trends associated with PCC in T2DM patients have shown complex trajectories, with notable disparities across demographic and geographic lines. Further research is needed to comprehensively understand the dynamics of PCC and its implications for public health.
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