ArticleBMC ophthalmology2025
Place of dexamethasone implant as an adjunctive treatment in Coats' disease: a retrospective single-center study.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adult-onset Coats disease: A systematic review and meta-analysis of imaging biomarkers and targeted therapies.Acta ophthalmologica · 2026Pooled it
- When Coats' disease meets a retinal break: adult-onset presentation with rhegmatogenous retinal detachment.BMC ophthalmology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the efficacy and safety of intravitreal dexamethasone implant as an adjunctive treatment to ablative therapy in Coats' disease.
methodsConsecutive Coats patients examined between February 2012 and January 2024 who received Dexamethasone implant with a follow-up for over twelve months were retrospectively evaluated. The demographic assessment, clinical staging, therapies, and clinical and anatomic outcomes were noted.
resultsOf 15 total patients, four were excluded due to short follow-up. Ten patients (90.9%) were male, and all had unilateral involvement, whereas the only female patient (9.1%) had bilateral disease at presentation. At admission, the mean age was 14.82 ± 17.27 years (range 2-60 years). Seven of 12 eyes (58.33%) had stage 3a1, three eyes (25%) had stage 3a2, and two eyes (16.67%) had stage 2b disease. The mean follow-up duration was 65.73 ± 41.81 months (range 18-131 months). At the last visit, visual acuity remained stable in six of 12 eyes (50%), deteriorated in two eyes (16.67%), and improved at least one Snellen line in four eyes (33.33%). Transient IOP elevation was noted in eight eyes (66.67%). Cataract progression was documented in seven (58.33%) eyes, and four had cataract surgery (33.33%). Cyberknife therapy and subsequent vitrectomy surgery were performed in one eye (8.33%) due to a secondary vasoproliferative tumor occurrence. No other dexamethasone implant-related complication was noted.
conclusionsIntravitreal dexamethasone implant can be a viable adjunctive option, especially in youngsters, to avoid frequent general anesthesia and in adults having massive macular exudation in addition to the conventional ablation treatments in Coats' patients.
trial registrationRetrospectively registered. The study adhered to the principles outlined in the Declaration of Helsinki and was approved by the local ethics committee (Date: 12.02.2025, Number: 2025/05-24).
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