Evidence map›Paper›PMID 40731266›Full record

ArticleBMC genomic data2025

Genomic characterization and phylogenetic analysis of respiratory syncytial virus F gene in Sri Lanka: a comparative study.

Thejanee Perera, Ishani De Silva, Pavithri Bandara, Asanka Bowatte, Dinithi Rathnayake, Shanika Perera, Saranga Sumathipala, Rohitha Muthugala

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomic data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thejanee PereraInstitute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, 00300, Sri Lanka.ORCID http://orcid.org/0000-0002-4667-6466
Ishani De SilvaTeaching Hospital Peradeniya, Peradeniya, 20400, Sri Lanka.
Pavithri BandaraTeaching Hospital Kurunagala, Kurunagala, 60000, Sri Lanka.
Asanka BowatteGenomic Laboratory, National Cancer Institute, Maharagama, 10280, Sri Lanka.
Dinithi RathnayakeGenomic Laboratory, National Cancer Institute, Maharagama, 10280, Sri Lanka.
Shanika PereraGenomic Laboratory, National Cancer Institute, Maharagama, 10280, Sri Lanka.
Saranga SumathipalaGenomic Laboratory, National Cancer Institute, Maharagama, 10280, Sri Lanka.
Rohitha MuthugalaNational Hospital Kandy, Kandy, 20000, Sri Lanka. rohithavm@yahoo.com.ORCID http://orcid.org/0000-0002-7546-1069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory Syncytial Virus (RSV) is a major cause of acute respiratory tract infections (ARTI) worldwide, with seasonal outbreaks often influenced by climatic factors. This study investigates the genetic diversity and phylogenetic relationships of RSV strains circulated in Sri Lanka between 2022 December and 2024 February.

resultsSubtyping of 12 RSV-positive samples identified both RSV A and B, with full-length F gene sequences obtained for four samples. Phylogenetic analysis revealed clustering with globally circulating strains. Mutation profiling highlighted key amino acid substitutions, including a rare mutation of N116D in the F protein, which may have functional implications. The limited sample size necessitates further studies with broader geographic coverage for more robust conclusions.

conclusionThis study provides insights into the genetic diversity of RSV F gene in Sri Lanka.

Indexed as

Genome, ViralGenomicsPhylogenyRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsViral Fusion ProteinsGenetic VariationHumansMutationSri LankaF protein, human respiratory syncytial virusViral Fusion ProteinsPublic healthRespiratory syncytial virusesRespiratory tract infectionsSri Lanka

Identifiers

PMID40731266
PMCPMC12308955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.